Interactions of RNA and RNA Recognition Motif (InteR3M)

InteR3M is a database about the structures and sequences of RNA Recognition Motifs (RRMs) and their interactions with RNA. RRM is the most common RNA-binding motif that has been identified; it is present in a significant number of proteins involved in almost all aspects of RNA processing and transport. RRMs are found in a variety of RNA binding proteins, including heterogeneous nuclear ribonucleoproteins (hnRNPs, P09651 in human or F1LQ48 in rat), sex-lethal protein (P19339 in Drosophila melanogaster) and Musashi (Q61474 or Q920Q6 in mouse and Q96DH6 in human). RRM adopts a typical β1α1β2β3α2β4 topology that forms a four-stranded β-sheet packed against two α-helices.

InteR3M uses the master alignment from Martinez et al., 2023 to align all the RRM domain structural instances.