Interactions of RNA and RNA Recognition Motif (InteR3M)

InteR3M is a database about the structures and sequences of RNA Recognition Motifs (RRMs) and their interactions with RNA. RRM is the most common RNA-binding motif that has been identified; it is present in a significant number of proteins involved in almost all aspects of RNA processing and transport. RRMs are found in a variety of RNA binding proteins, including heterogeneous nuclear ribonucleoproteins (hnRNPs, P09651 in human or F1LQ48 in rat), sex-lethal protein (P19339 in Drosophila melanogaster) and Musashi (Q61474 or Q920Q6 in mouse and Q96DH6 in human). RRM adopts a typical β1α1β2β3α2β4 topology that forms a four-stranded β-sheet packed against two α-helices.

InteR3M uses the master alignment from Martinez et al., 2023 to align all the RRM domain structural instances.

Canonical RRM Fold
Canonical RRM Fold

Get quick predictions for any RNA recognition motif (RRM) and any RNA target purely based on their sequences using RRMScorer .

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