Lupus La protein

Protein information

  • Protein ID: P05455
  • Protein Name : Lupus La protein
  • Gene : SSB
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525 PubMed:2470590). In case of Coxsackievirus B3 infection binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).

Protein Sequence

  • MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
P05455_RRM1 113 - 181 PF00076
P05455_RRM2 231 - 334 PF08777

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
P05455_linker1 182 - 230

Experiments retrieved for this Protein - 8 

Experiment ID Experiment Type PubMed ID
Exp_1OWX NMR 12842046
Exp_1S79 NMR 15004549
Exp_1YTY X-ray Diffraction 16387655
Exp_1ZH5 X-ray Diffraction 16387655
Exp_2VOD X-ray Diffraction 18547518
Exp_2VON X-ray Diffraction 18547518
Exp_2VOO X-ray Diffraction 18547518
Exp_2VOP X-ray Diffraction 18547518

Ligands tested for Binding - 5 

Ligand ID Ligand Type Ligand Sequence
Lig160 RNA AUUUU
Lig177 RNA UGCUGUUUU
Lig199 RNA AUAAUUU
Lig34 RNA AUAUUUU
Lig54 RNA UUUUUUU