Nucleolin

Protein information

  • Protein ID: P08199
  • Protein Name : Nucleolin
  • Gene : NCL
  • Organism : Mesocricetus auratus
  • Status : reviewed
  • Function : Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).

Protein Sequence

  • MVKLAKAGKTHGEAKKMAPPPKEVEEDSEDEEMSEEEDDSSGEEVVIPQKKGKKATATPAKKVVVSQTKKVAVPTPAKKAAVTPGKKAAATPAKKAVTPAKAVATPGKKGATQAKALVATPGKKGAVTPAKGAKNGKNAKKEDSDEDEDDDDDEDDSDEDEEDEEEDEFEPPVVKGKQGKVAAAAPASEDEDEEEDEEEEEEDEEEEDDSEEEEAMEITPAKGKKAPAKVVPVKAKNVAEEDDDDEEEDEDEEEDEEEEEDEEEEEEEEEEEPVKPAPGKRKKEMTKQKEVPEAKKQKVEGSESTTPFNLFIGNLNPNKSVAELKVAISEPFAKNDLAVVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFEDALEIRLVSQDGKSKGIAYIEFKSEADAEKNLEEKQGAEIDGRSVSLYYTGEKGQRQERTGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQQGKSKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFEGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGGRGGFGGRGRGGFGGRGGFRGGRGGGGGGGDFKPQGKKTKFE

RRM domains in this Protein - 4 

RRM Entryname RRM Sequence range Pfam ID
P08199_RRM1 310 - 378 PF00076
P08199_RRM2 396 - 461 PF00076
P08199_RRM3 488 - 554 PF00076
P08199_RRM4 574 - 641 PF00076

RRM domain Linkers in this Protein - 3 

Linker Name Linker Sequence range
P08199_linker1 379 - 395
P08199_linker2 462 - 487
P08199_linker3 555 - 573

Experiments retrieved for this Protein - 4 

Experiment ID Experiment Type PubMed ID
Exp_1FJ7 NMR 11023788
Exp_1FJC NMR 11023788
Exp_1FJE NMR 11118222
Exp_1RKJ NMR 15033352

Ligands tested for Binding - 4 

Ligand ID Ligand Type Ligand Sequence
Lig164 RNA GGAUGCCUCCCGAGUGCAUCC
Lig191 RNA GGCCGAAAUCCCGAAGUAGGCC
Lig164 RNA GGAUGCCUCCCGAGUGCAUCC
Lig191 RNA GGCCGAAAUCCCGAAGUAGGCC