Heterogeneous nuclear ribonucleoprotein A1

Protein information

  • Protein ID: P09651
  • Protein Name : Heterogeneous nuclear ribonucleoprotein A1
  • Gene : HNRNPA1
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Involved in the packaging of pre-mRNA into hnRNP particles transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9 inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233).

Protein Sequence

  • MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
P09651_RRM1 16 - 85 PF00076
P09651_RRM2 107 - 176 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
P09651_linker1 86 - 106

Experiments retrieved for this Protein - 19 

Experiment ID Experiment Type PubMed ID
Exp_1HA1 X-ray Diffraction 9164463
Exp_1L3K X-ray Diffraction 11917013
Exp_1PGZ X-ray Diffraction 12904298
Exp_1PO6 X-ray Diffraction 12904298
Exp_1U1K X-ray Diffraction 15342234
Exp_1U1L X-ray Diffraction 15342234
Exp_1U1M X-ray Diffraction 15342234
Exp_1U1N X-ray Diffraction 15342234
Exp_1U1O X-ray Diffraction 15342234
Exp_1U1P X-ray Diffraction 15342234
Exp_1U1Q X-ray Diffraction 15342234
Exp_1U1R X-ray Diffraction 15342234
Exp_1UP1 X-ray Diffraction 9115444
Exp_2LYV NMR 23247503
Exp_2UP1 X-ray Diffraction 10323862
Exp_4YOE X-ray Diffraction 26003924
Exp_5MPG NMR 28650318
Exp_5MPL NMR 28650318
Exp_6DCL X-ray Diffraction 29946118

Ligands tested for Binding - 12 

Ligand ID Ligand Type Ligand Sequence
Lig103 DNA TAGGGTTAIGG
Lig119 RNA UUAGGUC
Lig124 RNA AGUAGAUUAGCA
Lig139 DNA TAGGGTTAGIG
Lig146 DNA TTAGGGTTAGGG
Lig162 DNA TAGGNTTAGGG
Lig188 RNA AGU
Lig30 DNA TTAGGGTTAGNG
Lig67 DNA TAGGGTTAGGG
Lig71 DNA TAGGGTTAAGG
Lig124 RNA AGUAGAUUAGCA
Lig86 RNA UCAGUU