ATP-dependent RNA helicase DeaD

Protein information

  • Protein ID: P0A9P6
  • Protein Name : ATP-dependent RNA helicase DeaD
  • Gene : deaD
  • Organism : Escherichia coli (strain K12)
  • Status : reviewed
  • Function : DEAD-box RNA helicase involved in various cellular processes at low temperature including ribosome biogenesis mRNA degradation and translation initiation. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity at low temperature. Involved in 50S ribosomal subunit assembly acting after SrmB and could also play a role in the biogenesis of the 30S ribosomal subunit. In addition is involved in mRNA decay via formation of a cold-shock degradosome with RNase E. Also stimulates translation of some mRNAs probably at the level of initiation.

Protein Sequence

  • MAEFETTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLQNLDPELKAPQILVLAPTRELAVQVAEAMTDFSKHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIERTMKLTIPEVELPNAELLGKRRLEKFAAKVQQQLESSDLDQYRALLSKIQPTAEGEELDLETLAAALLKMAQGERTLIVPPDAPMRPKREFRDRDDRGPRDRNDRGPRGDREDRPRRERRDVGDMQLYRIEVGRDDGVEVRHIVGAIANEGDISSRYIGNIKLFASHSTIELPKGMPGEVLQHFTRTRILNKPMNMQLLGDAQPHTGGERRGGGRGFGGERREGGRNFSGERREGGRGDGRRFSGERREGRAPRRDDSTGRRRFGGDA

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
P0A9P6_RRM1 488 - 559 PF03880

Experiments retrieved for this Protein - 1 

Experiment ID Experiment Type PubMed ID
Exp_5B88 NMR 29107486