Negative elongation factor E

Protein information

  • Protein ID: P18615
  • Protein Name : Negative elongation factor E
  • Gene : NELFE
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Essential component of the NELF complex a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401 PubMed:27256882). The NELF complex which acts via an association with the DSIF complex and causes transcriptional pausing is counteracted by the P-TEFb kinase complex (PubMed:11940650 PubMed:12612062 PubMed:27256882). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858 PubMed:27282391 PubMed:27256882).

Protein Sequence

  • MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSSTTSQGGVKRSLSEQPVMDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDDLQESSRRPQRKSLYESFVSSSDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSASPPRSRSRDRSHERNRDRDRDRERDRDRDRDRDRERDRDRDRDRDRDRERDRDRERDRDRDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDVYKENLVDGF

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
P18615_RRM1 267 - 326 PF00076

Experiments retrieved for this Protein - 3 

Experiment ID Experiment Type PubMed ID
Exp_1X5P NMR
Exp_2BZ2 NMR 16898873
Exp_2JX2 NMR 18303858