Serine/arginine (SR)-type shuttling mRNA binding protein GBP2

Protein information

  • Protein ID: P25555
  • Protein Name : Serine/arginine (SR)-type shuttling mRNA binding protein GBP2
  • Gene : GBP2
  • Organism : Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
  • Status : reviewed
  • Function : Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus (PubMed:14769921 PubMed:24452287). Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded. On correctly spliced mRNAs GBP2 and HRB1 recruit MEX67 to allow nuclear export. On faulty mRNAs GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation (PubMed:24452287). Binds single-stranded telomeric sequences of the type (TG[1-3])n in vitro (PubMed:7800479). Influences the localization of RAP1 in the nuclei (PubMed:7777547). Involved in modulating telomere length (PubMed:12519786).

Protein Sequence

  • MERELGMYGNDRSRSRSPVRRRLSDDRDRYDDYNDSSSNNGNGSRRQRRDRGSRFNDRYDQSYGGSRYHDDRNWPPRRGGRGRGGSRSFRGGRGGGRGRTLGPIVERDLERQFDATKRNFENSIFVRNLTFDCTPEDLKELFGTVGEVVEADIITSKGHHRGMGTVEFTKNESVQDAISKFDGALFMDRKLMVRQDNPPPEAAKEFSKKATREEIDNGFEVFIINLPYSMNWQSLKDMFKECGHVLRADVELDFNGFSRGFGSVIYPTEDEMIRAIDTFNGMEVEGRVLEVREGRFNKRKNNDRYNQRREDLEDTRGTEPGLAQDAAVHIDETAAKFTEGVNPGGDRNCFIYCSNLPFSTARSDLFDLFGPIGKINNAELKPQENGQPTGVAVVEYENLVDADFCIQKLNNYNYGGCSLQISYARRD

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
P25555_RRM1 124 - 192 PF00076
P25555_RRM2 221 - 290 PF00076
P25555_RRM3 351 - 420 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
P25555_linker1 193 - 220
P25555_linker2 291 - 350

Experiments retrieved for this Protein - 1 

Experiment ID Experiment Type PubMed ID
Exp_2MZQ NMR 26602689