Heterogeneous nuclear ribonucleoprotein H

Protein information

  • Protein ID: P31943
  • Protein Name : Heterogeneous nuclear ribonucleoprotein H
  • Gene : HNRNPH1
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits together with CUGBP1 insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).

Protein Sequence

  • MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDFQSNIA

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
P31943_RRM1 13 - 84 PF00076
P31943_RRM2 113 - 182 PF00076
P31943_RRM3 291 - 358 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
P31943_linker1 85 - 112
P31943_linker2 183 - 290

Experiments retrieved for this Protein - 2 

Experiment ID Experiment Type PubMed ID
Exp_2LXU NMR
Exp_6DHS X-ray Diffraction 30122033