Serine/arginine (SR)-type shuttling mRNA binding protein HRB1

Protein information

  • Protein ID: P38922
  • Protein Name : Serine/arginine (SR)-type shuttling mRNA binding protein HRB1
  • Gene : HRB1
  • Organism : Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
  • Status : reviewed
  • Function : Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus (PubMed:14676199 PubMed:14769921 PubMed:24452287). Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded. On correctly spliced mRNAs GBP2 and HRB1 recruit MEX67 to allow nuclear export. On faulty mRNAs GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation (PubMed:24452287).

Protein Sequence

  • MSDQERGSENNNRSRSRSRSPVRRRMSDDHGYERDNHLSRRSGNYNGRRKFADTYRGSRDRGEYRGGRERSDYRERERFNNRDNPRSRDRYDDRRRGRDVTGRYGNRRDDYPRSFRSRHNTRDDSRRGGFGSSGARGDYGPLLARELDSTYEEKVNRNYSNSIFVGNLTYDSTPEDLTEFFSQIGKVVRADIITSRGHHRGMGTVEFTNSDDVDRAIRQYDGAFFMDRKIFVRQDNPPPSNNIKERKALDRGELRHNRKTHEVIVKNLPASVNWQALKDIFKECGNVAHADVELDGDGVSTGSGTVSFYDIKDLHRAIEKYNGYSIEGNVLDVKSKESVHNHSDGDDVDIPMDDSPVNEEARKFTENVVGGGERNRLIYCSNLPFSTAKSDLYDLFETIGKVNNAELRYDSKGAPTGIAVVEYDNVDDADVCIERLNNYNYGGCDLDISYAKRL

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
P38922_RRM1 163 - 230 PF00076
P38922_RRM2 263 - 332 PF00076
P38922_RRM3 378 - 447 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
P38922_linker1 231 - 262
P38922_linker2 333 - 377

Experiments retrieved for this Protein - 3 

Experiment ID Experiment Type PubMed ID
Exp_2MZR NMR 26602689
Exp_2MZS NMR 26602689
Exp_2MZT NMR 26602689