U1 small nuclear ribonucleoprotein A

Protein information

  • Protein ID: P43332
  • Protein Name : U1 small nuclear ribonucleoprotein A
  • Gene : snf
  • Organism : Drosophila melanogaster
  • Status : reviewed
  • Function : Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). Plays a role in regulating sex-lethal splicing.

Protein Sequence

  • MEMLPNQTIYINNLNEKIKKEELKKSLYAIFSQFGQILDIVALKTLKMRGQAFVIFKEIGSASNALRTMQGFPFYDKPMQIAYSKSDSDIVAKIKGTFKERPKKVKPPKPAPGTDEKKDKKKKPSSAENSNPNAQTEQPPNQILFLTNLPEETNEMMLSMLFNQFPGFKEVRLVPNRHDIAFVEFTTELQSNAAKEALQGFKITPTHAMKITFAKK

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
P43332_RRM1 9 - 80 PF00076
P43332_RRM2 144 - 209 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
P43332_linker1 81 - 143

Experiments retrieved for this Protein - 7 

Experiment ID Experiment Type PubMed ID
Exp_2AYM NMR
Exp_2B0G NMR
Exp_2K3K NMR
Exp_6F4G X-ray Diffraction 29880797
Exp_6F4H X-ray Diffraction 29880797
Exp_6F4I X-ray Diffraction 29880797
Exp_6F4J X-ray Diffraction 29880797

Ligands tested for Binding - 2 

Ligand ID Ligand Type Ligand Sequence
Lig144 RNA GGCCGCAUUGCACCUCGCGGCC
Lig207 RNA GCGGCCGUAUUGCAGUACCGCGGCC