Heterogeneous nuclear ribonucleoprotein M

Protein information

  • Protein ID: P52272
  • Protein Name : Heterogeneous nuclear ribonucleoprotein M
  • Gene : HNRNPM
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Pre-mRNA binding protein in vivo binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha IL-6 IL-10 and tumor necrosis factor alpha cytokines.

Protein Sequence

  • MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
P52272_RRM1 73 - 143 PF00076
P52272_RRM2 206 - 275 PF00076
P52272_RRM3 655 - 723 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
P52272_linker1 144 - 205
P52272_linker2 276 - 654

Experiments retrieved for this Protein - 3 

Experiment ID Experiment Type PubMed ID
Exp_2DGV NMR
Exp_2DH9 NMR
Exp_2DO0 NMR