Heterogeneous nuclear ribonucleoprotein F

Protein information

  • Protein ID: P52597
  • Protein Name : Heterogeneous nuclear ribonucleoprotein F
  • Gene : HNRNPF
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.

Protein Sequence

  • MMLGPEGGEGFVVKLRGLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTREGRQSGEAFVELGSEDDVKMALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLERMRPGAYSTGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
P52597_RRM1 113 - 182 PF00076
P52597_RRM2 291 - 358 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
P52597_linker1 183 - 290

Experiments retrieved for this Protein - 4 

Experiment ID Experiment Type PubMed ID
Exp_2HGM NMR 16885237
Exp_2HGN NMR 16885237
Exp_2KG0 NMR 20526337
Exp_2KG1 NMR 20526337

Ligands tested for Binding - 2 

Ligand ID Ligand Type Ligand Sequence
Lig134 RNA AGGGAU
Lig134 RNA AGGGAU