Splicing factor U2AF 35 kDa subunit

Protein information

  • Protein ID: Q01081
  • Protein Name : Splicing factor U2AF 35 kDa subunit
  • Gene : U2AF1
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron.

Protein Sequence

  • MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQSADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
Q01081_RRM1 82 - 141 PF00076

Experiments retrieved for this Protein - 1 

Experiment ID Experiment Type PubMed ID
Exp_1JMT X-ray Diffraction 11551507