RNA-binding protein 39

Protein information

  • Protein ID: Q14498
  • Protein Name : RNA-binding protein 39
  • Gene : RBM39
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343 PubMed:31271494 PubMed:28437394 PubMed:28302793 PubMed:24795046). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta and JUN/AP-1 independently of the pre-mRNA splicing factor activity (By similarity).

Protein Sequence

  • MADDIDIEAMLEAPYKKDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLLVPSRR

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
Q14498_RRM1 155 - 223 PF00076
Q14498_RRM2 252 - 322 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
Q14498_linker1 224 - 251

Experiments retrieved for this Protein - 10 

Experiment ID Experiment Type PubMed ID
Exp_2JRS NMR
Exp_2MHN NMR
Exp_4YUD X-ray Diffraction
Exp_6PAI X-ray Diffraction 31693911
Exp_6Q0R X-ray Diffraction 31686031
Exp_6Q0V X-ray Diffraction 31686031
Exp_6Q0W X-ray Diffraction 31686031
Exp_6SJ7 EM 31819272
Exp_6UD7 X-ray Diffraction 31819272
Exp_6UE5 X-ray Diffraction 31819272