Cytoplasmic polyadenylation element-binding protein 4
Protein information
Protein ID: Q17RY0
Protein Name : Cytoplasmic polyadenylation element-binding protein 4
Gene : CPEB4
Organism : Homo sapiens
Status : reviewed
Function : Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE) an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3 does not play role in synaptic plasticity learning and memory (By similarity).