CUGBP Elav-like family member 1

Protein information

  • Protein ID: Q28HE9
  • Protein Name : CUGBP Elav-like family member 1
  • Gene : celf1
  • Organism : Xenopus tropicalis
  • Status : reviewed
  • Function : RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in pre-mRNA alternative splicing mRNA translation activation and stability (By similarity). Mediates the rapid and sequence-specific cytoplasmic deadenylation of EDEN-containing maternal mRNAs following fertilization. Binds to AU-rich sequences (AREs) of jun mRNA. Binds to the embryonic deadenylation element (EDEN) motif localized in the 3'-UTR of maternal mRNAs. Binds to RNA containing several repeats of the consensus sequence 5'-UGU-3'. EDEN-dependent deadenylation is enhanced by the presence of an additional cis element composed of three AUU repeats (By similarity).

Protein Sequence

  • MNGTMDHPDHPDPDSIKMFVGQVPRSWSEKELRELFEQYGAVYEINVLRDRSQNPPQSKGCCFITFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFVGMVSKKCNENDIRAMFSQFGQIEESRILRGPDGMSRGCAFVTFTTRSMAQMAIKAMHQAQTMEGCSSPIVVKFADTQKDKEQKRMTQQLQQQMQQLNAASMWGNLAGLSSLAPQYLALLQQTASSGNLNSLSGLHPMGGEYATGMTSGLNAMQLQNLAALAAAASAAQNTPSAGSALTTSSSPLSILTSSGSSPSSNNNSAVNPMASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSLSNGTGSTMEALSQAYSGIQQYAAAALPSLYNQSLLSQQGLGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
Q28HE9_RRM1 18 - 88 PF00076
Q28HE9_RRM2 110 - 178 PF00076
Q28HE9_RRM3 407 - 477 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
Q28HE9_linker1 89 - 109
Q28HE9_linker2 179 - 406

Experiments retrieved for this Protein - 5 

Experiment ID Experiment Type PubMed ID
Exp_303 ITC 21743084
Exp_304 ITC 21743084
Exp_305 ITC 21743084
Exp_306 ITC 21743084
Exp_307 ITC 21743084

Ligands tested for Binding - 10 

Ligand ID Ligand Type Ligand Sequence
Lig257 RNA UGUUUUGU
Lig275 RNA UGUUUUUUUGU
Lig290 RNA UGU
Lig322 RNA UGUUUUUUGU
Lig331 RNA UGUUUUUUUUGU
Lig257 RNA UGUUUUGU
Lig275 RNA UGUUUUUUUGU
Lig290 RNA UGU
Lig322 RNA UGUUUUUUGU
Lig331 RNA UGUUUUUUUUGU