CUGBP Elav-like family member 3

Protein information

  • Protein ID: Q5SZQ8
  • Protein Name : CUGBP Elav-like family member 3
  • Gene : CELF3
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Protein Sequence

  • MKEPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYTGLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAFVKFQTHAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIALQFGAYSAYTQALMQQQAALVAAHSAYLSPMATMAAVQMQHMAAINANGLIATPITPSSGTSTPPAIAATPVSAIPAALGVNGYSPVPTQPTGQPAPDALYPNGVHPYPAQSPAAPVDPLQQAYAGMQHYTAAYPAAYSLVAPAFPQPPALVAQQPPPPPQQQQQQQQQQQQQQQREGPDGCNIFIYHLPQEFTDSEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
Q5SZQ8_RRM1 9 - 78 PF00076
Q5SZQ8_RRM2 97 - 165 PF00076
Q5SZQ8_RRM3 382 - 452 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
Q5SZQ8_linker1 79 - 96
Q5SZQ8_linker2 166 - 381

Experiments retrieved for this Protein - 1 

Experiment ID Experiment Type PubMed ID
Exp_2DNO NMR