ELAV-like protein 3

Protein information

  • Protein ID: Q60900
  • Protein Name : ELAV-like protein 3
  • Gene : Elavl3
  • Organism : Mus musculus
  • Status : reviewed
  • Function : RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs including VEGF mRNA (PubMed:10734193 PubMed:9016658). May also bind poly-A tracts via RRM 3 (PubMed:9016658). May be involved in neuronal differentiation and maintenance (PubMed:9016658). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (PubMed:11573004).

Protein Sequence

  • MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILLDQATGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
Q60900_RRM1 41 - 111 PF00076
Q60900_RRM2 127 - 195 PF00076
Q60900_RRM3 286 - 356 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
Q60900_linker1 112 - 126
Q60900_linker2 196 - 285

Experiments retrieved for this Protein - 3 

Experiment ID Experiment Type PubMed ID
Exp_1D8Z NMR 10734193
Exp_1D9A NMR 10734193
Exp_1FNX NMR

Ligands tested for Binding - 2 

Ligand ID Ligand Type Ligand Sequence
Lig137 RNA UAUUUAUUUU
Lig137 RNA UAUUUAUUUU