Putative RNA-binding protein 15B

Protein information

  • Protein ID: Q6PHZ5
  • Protein Name : Putative RNA-binding protein 15B
  • Gene : Rbm15b
  • Organism : Mus musculus
  • Status : reviewed
  • Function : RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs thereby regulating different processes such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex a complex that mediates N6-methyladenosine (m6A) methylation of RNAs a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex which mediates m6A methylation leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1.

Protein Sequence

  • MKRQSERDSSPSGRGSSSSAKRPREREREAEAGGRRAAHKASGGTKHPVPARARDKPRGSGGGGGHRDGRAAGDANHRASGGRSSGAPGGGGRTGKASGDPGAGGASPRASPLPPPPPPPGAEPAGPGSTAAPEYKTLLISSLSPALPAEHLEDRLFHQFKRFGEISLRLSHTPELGRVAYVNFRHPQDAREARQHALARQLLLYDRPLKVEPVYLRGGGSSRRSSSSSAAASTPPPGPPAPADPLGYLPLHGGYQYKQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRERALDYYGLYDDRGRPYGYQAVCEEDLMPEDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSFAYIQYESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAEETRYPQQYQPSPLPVHYELLTDGYTRHRNLDADLRVRDRTPPHLLYSDRDRTFLEGDWTSLSKSSDRRNSLEGYSRSVRSRSGERWGGDGDRSIAKPWEERRKRRSLSSDRGRTTHSPYEERSRTKGGGQQSERGSDRTPERSRKENHSSEGTKESGSNSLSNSRHGAEERSHHHHHHEAPDSSHGKKTRESERNHRTTEAEPKTLEEPKHETKKLKTLSEYAQTLQLGWNGLLVLKNSCFPTSMHILEGDQGVISGLLKDHPSGSKLTQLKIAQRLRLDQPKLDEVTRRIKQGSPNGYAVLLAIQSTPSGPGAEGMPVVEPGLQRRLLRNLVSYLKQKQAAGVISLPVGGSKGRDNTGMLYAFPPCDFSQQYLQSALRTLGKLEEEHMVIVIVRDTA

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
Q6PHZ5_RRM1 335 - 404 PF00076
Q6PHZ5_RRM2 416 - 478 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
Q6PHZ5_linker1 405 - 415

Experiments retrieved for this Protein - 1 

Experiment ID Experiment Type PubMed ID
Exp_1WHY NMR