CUGBP Elav-like family member 5

Protein information

  • Protein ID: Q8N6W0
  • Protein Name : CUGBP Elav-like family member 5
  • Gene : CELF5
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Protein Sequence

  • MARLTESEARRQQQQLLQPRPSPVGSSGPEPPGGQPDGMKDLDAIKLFVGQIPRHLDEKDLKPLFEQFGRIYELTVLKDPYTGMHKGCAFLTYCARDSAIKAQTALHEQKTLPGMARPIQVKPADSESRGGRDRKLFVGMLNKQQSEEDVLRLFQPFGVIDECTVLRGPDGSSKGCAFVKFSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDKERTLRRMQQMVGQLGILTPSLTLPFSPYSAYAQALMQQQTTVLSTSGSYLSPGVAFSPCHIQQIGAVSLNGLPATPIAPASGLHSPPLLGTTAVPGLVAPITNGFAGVVPFPGGHPALETVYANGLVPYPAQSPTVAETLHPAFSGVQQYTAMYPTAAITPIAHSVPQPPPLLQQQQREGPEGCNLFIYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDPGHPY

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
Q8N6W0_RRM1 47 - 116 PF00076
Q8N6W0_RRM2 136 - 204 PF00076
Q8N6W0_RRM3 402 - 472 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
Q8N6W0_linker1 117 - 135
Q8N6W0_linker2 205 - 401

Experiments retrieved for this Protein - 1 

Experiment ID Experiment Type PubMed ID
Exp_2DNH NMR