Heterogeneous nuclear ribonucleoprotein L

Protein information

  • Protein ID: Q8R081
  • Protein Name : Heterogeneous nuclear ribonucleoprotein L
  • Gene : Hnrnpl
  • Organism : Mus musculus
  • Status : reviewed
  • Function : Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion (PubMed:22523384). Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates together with APEX1 to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827 HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).

Protein Sequence

  • MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
Q8R081_RRM1 101 - 159 PF00076
Q8R081_RRM2 181 - 267 PF11835
Q8R081_RRM3 353 - 477 PF13893

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
Q8R081_linker1 160 - 180
Q8R081_linker2 268 - 352

Experiments retrieved for this Protein - 2 

Experiment ID Experiment Type PubMed ID
Exp_3S01 X-ray Diffraction
Exp_3TYT X-ray Diffraction