Protein INVOLVED IN DE NOVO 2

Protein information

  • Protein ID: Q8VZ79
  • Protein Name : Protein INVOLVED IN DE NOVO 2
  • Gene : IDN2
  • Organism : Arabidopsis thaliana
  • Status : reviewed
  • Function : Forms a complex with FDM1/IDNL1 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (PubMed:22570638 PubMed:22592791) and downstream of small interfering RNA (siRNA) formation (PubMed:22810086). Required for de novo DNA methylation siRNA accumulation and siRNA-mediated maintenance methylation (PubMed:19915591). Required for several post-transcriptional gene silencing pathways (PubMed:20059743). Binds double-stranded RNAs (dsRNAs) with 5'-overhangs through its XS domain (PubMed:19915591 PubMed:20059743). Binds long non-coding RNA (lncRNA) in an AGO4-dependent manner and associates with DRM2 resulting in DNA methylation of RdDM target loci (PubMed:23246435 PubMed:24862207). Mediates the silencing of a subset of MORC6 target loci (PubMed:27171427).

Protein Sequence

  • MGSTVILSSDDEDSDISESEMDEYGDKMYLNLKGGKLKVRLSPQAFICPYCPNKKKTSFQYKDLLQHASGVGNSNSDKRSAKEKASHLALVKYLQQDLADSASEAEPSSKRQKNGNPIQDCDHDEKLVYPWKGIVVNIPTTKAQDGRSAGESGSKLRDEYILRGFNPTRVRPLWNYLGHSGTAIVEFNKDWNGLHNGLLFDKAYTVDGHGKKDWLKKDGPKLGLYGWIARADDYNGNNIIGENLRKTGDLKTIAELTEEEARKQELLVQNLRQLVEEKKKDMKEIEELCSVKSEELNQLMEEKEKNQQKHYRELNAIQERTMSHIQKIVDDHEKLKRLLESERKKLEIKCNELAKREVHNGTERMKLSEDLEQNASKNSSLELAAMEQQKADEEVKKLAEDQRRQKEELHEKIIRLERQRDQKQAIELEVEQLKGQLNVMKHMASDGDAEVVKEVDIIFKDLGEKEAQLADLDKFNQTLILRERRTNDELQEAHKELVNIMKEWNTNIGVKRMGELVTKPFVDAMQQKYCQQDVEDRAVEVLQLWEHYLKDSDWHPFKRVKLENEDREVEVIDDRDEKLRELKADLGDGPYNAVTKALLEINEYNPSGRYITTELWNFKADKKATLEEGVTCLLDQWEKAKRKRGMA

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
Q8VZ79_RRM1 124 - 236 PF03468

Experiments retrieved for this Protein - 1 

Experiment ID Experiment Type PubMed ID
Exp_4E8U X-ray Diffraction 22592791