Paraspeckle component 1

Protein information

  • Protein ID: Q8WXF1
  • Protein Name : Paraspeckle component 1
  • Gene : PSPC1
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Regulates cooperatively with NONO and SFPQ androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A) poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

Protein Sequence

  • MMLRGNLKQVRIEKNPARLRALESAVGESEPAAAAAMALALAGEPAPPAPAPPEDHPDEEMGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGNQGPPPMMGMNMNNRATIPGPPMGPGPAMGPEGAANMGTPMMPDNGAVHNDRFPQGPPSQMGSPMGSRTGSETPQAPMSGVGPVSGGPGGFGRGSQGGNFEGPNKRRRY

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
Q8WXF1_RRM1 84 - 148 PF00076
Q8WXF1_RRM2 158 - 223 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
Q8WXF1_linker1 149 - 157

Experiments retrieved for this Protein - 3 

Experiment ID Experiment Type PubMed ID
Exp_3SDE X-ray Diffraction 22416126
Exp_5IFN X-ray Diffraction
Exp_5WPA X-ray Diffraction 29530979