TAR DNA-binding protein 43

Protein information

  • Protein ID: Q921F2
  • Protein Name : TAR DNA-binding protein 43
  • Gene : Tardbp
  • Organism : Mus musculus
  • Status : reviewed
  • Function : RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds via its two RNA recognition motifs RRM1 and RRM2 to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (By similarity). Participates also in the normal skeletal muscle formation and regeneration forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (By similarity). Regulates the expression of HDAC6 ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563).

Protein Sequence

  • MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSPDEPLRSRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
Q921F2_RRM1 106 - 172 PF00076
Q921F2_RRM2 193 - 243 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
Q921F2_linker1 173 - 192

Experiments retrieved for this Protein - 1 

Experiment ID Experiment Type PubMed ID
Exp_3D2W X-ray Diffraction 19174564

Ligands tested for Binding - 1 

Ligand ID Ligand Type Ligand Sequence
Lig106 DNA GTTGAGCGTT