RNA-binding protein with multiple splicing

Protein information

  • Protein ID: Q93062
  • Protein Name : RNA-binding protein with multiple splicing
  • Gene : RBPMS
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2 SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2 SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224 PubMed:26347403).

Protein Sequence

  • MNNGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPASLHAQMRWLPPSEATSQGWKSRQFC

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
Q93062_RRM1 26 - 89 PF00076

Experiments retrieved for this Protein - 2 

Experiment ID Experiment Type PubMed ID
Exp_5CYJ X-ray Diffraction 26347403
Exp_5DET X-ray Diffraction 26347403

Ligands tested for Binding - 2 

Ligand ID Ligand Type Ligand Sequence
Lig111 RNA UCAC
Lig7 RNA UCACU