Protein Name : RNA-binding protein with multiple splicing
Gene : RBPMS
Organism : Homo sapiens
Status : reviewed
Function : Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2 SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2 SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224 PubMed:26347403).