CUGBP Elav-like family member 6

Protein information

  • Protein ID: Q96J87
  • Protein Name : CUGBP Elav-like family member 6
  • Gene : CELF6
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.

Protein Sequence

  • MAAAPGGSAQPAGPGPRLGFSTADSGVGMSGLNPGPAVPMKDHDAIKLFVGQIPRGLDEQDLKPLFEEFGRIYELTVLKDRLTGLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPAASEGRGEDRKLFVGMLGKQQGEEDVRRLFQPFGHIEECTVLRSPDGTSKGCAFVKFGSQGEAQAAIRGLHGSRTMAGASSSLVVKLADTDRERALRRMQQMAGHLGAFHPAPLPLGACGAYTTAILQHQAALLAAAQGPGLGPVAAVAAQMQHVAAFSLVAAPLLPAAAANSPPGSGPGTLPGLPAPIGVNGFGPLTPQTNGQPGSDTLYNNGLSPYPAQSPGVADPLQQAYAGMHHYAAAYPSAYAPVSTAFPQQPSALPQQQREGPEGCNLFIYHLPQEFGDAELIQTFLPFGAVVSAKVFVDRATNQSKCFGFVSFDNPTSAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
Q96J87_RRM1 48 - 117 PF00076
Q96J87_RRM2 136 - 204 PF00076
Q96J87_RRM3 398 - 468 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
Q96J87_linker1 118 - 135
Q96J87_linker2 205 - 397

Experiments retrieved for this Protein - 1 

Experiment ID Experiment Type PubMed ID
Exp_2DGQ NMR