Nuclear polyadenylated RNA-binding protein 4

Protein information

  • Protein ID: Q99383
  • Protein Name : Nuclear polyadenylated RNA-binding protein 4
  • Gene : HRP1
  • Organism : Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
  • Status : reviewed
  • Function : RNA-binding protein which is involved in the polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with the cleavage factor CFIA complex and the cleavage and polyadenylation factor (CPF) complex. May be involved in regulation of poly(A) site selection. Is involved in nonsense-mediated mRNA decay. Seems to bind to an RNA downstream sequence element (DSE) located 3' of a nonsense codon and may mark the transcript for decay.

Protein Sequence

  • MSSDEEDFNDIYGDDKPTTTEEVKKEEEQNKAGSGTSQLDQLAALQALSSSLNKLNNPNSNNSSSNNSNQDTSSSKQDGTANDKEGSNEDTKNEKKQESATSANANANASSAGPSGLPWEQLQQTMSQFQQPSSQSPPQQQVTQTKEERSKADLSKESCKMFIGGLNWDTTEDNLREYFGKYGTVTDLKIMKDPATGRSRGFGFLSFEKPSSVDEVVKTQHILDGKVIDPKRAIPRDEQDKTGKIFVGGIGPDVRPKEFEEFFSQWGTIIDAQLMLDKDTGQSRGFGFVTYDSADAVDRVCQNKFIDFKDRKIEIKRAEPRHMQQKSSNNGGNNGGNNMNRRGGNFGNQGDFNQMYQNPMMGGYNPMMNPQAMTDYYQKMQEYYQQMQKQTGMDYTQMYQQQMQQMAMMMPGFAMPPNAMTLNQPQQDSNATQGSPAPSDSDNNKSNDVQTIGNTSNTDSGSPPLNLPNGPKGPSQYNDDHNSGYGYNRDRGDRDRNDRDRDYNHRSGGNHRRNGRGGRGGYNRRNNGYHPYNR

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
Q99383_RRM1 161 - 229 PF00076
Q99383_RRM2 245 - 314 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
Q99383_linker1 230 - 244

Experiments retrieved for this Protein - 2 

Experiment ID Experiment Type PubMed ID
Exp_2CJK NMR 16794580
Exp_2KM8 NMR 20600122

Ligands tested for Binding - 4 

Ligand ID Ligand Type Ligand Sequence
Lig187 RNA UAUAUAUA
Lig44 RNA UAUAUAUAAUAAU
Lig187 RNA UAUAUAUA
Lig44 RNA UAUAUAUAAUAAU