CUGBP Elav-like family member 4

Protein information

  • Protein ID: Q9BZC1
  • Protein Name : CUGBP Elav-like family member 4
  • Gene : CELF4
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Protein Sequence

  • MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLFIYHLPQEFGDAELMQMFLPFGFVSFDNPASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
Q9BZC1_RRM1 56 - 125 PF00076
Q9BZC1_RRM2 154 - 222 PF00076
Q9BZC1_RRM3 430 - 473 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
Q9BZC1_linker1 126 - 153
Q9BZC1_linker2 223 - 429

Experiments retrieved for this Protein - 2 

Experiment ID Experiment Type PubMed ID
Exp_2DGP NMR
Exp_2DNK NMR