RNA-binding protein 38

Protein information

  • Protein ID: Q9H0Z9
  • Protein Name : RNA-binding protein 38
  • Gene : RBM38
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts leading to maintain the stability of CDKN1A transcripts thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1 but not isoform 2 has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.

Protein Sequence

  • MLLQPAPCAPSAGFPRPLAAPGAMHGSQKDTTFTKIFVGGLPYHTTDASLRKYFEGFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRSLQTGFAIGVQQLHPTLIQRTYGLTPHYIYPPAIVQPSVVIPAAPVPSLSSPYIEYTPASPAYAQYPPATYDQYPYAASPATAASFVGYSYPAAVPQALSAAAPAGTTFVQYQAPQLQPDRMQ

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
Q9H0Z9_RRM1 36 - 103 PF00076

Experiments retrieved for this Protein - 3 

Experiment ID Experiment Type PubMed ID
Exp_2CQD NMR
Exp_6JVX X-ray Diffraction 31860021
Exp_6JVY X-ray Diffraction 31860021

Ligands tested for Binding - 2 

Ligand ID Ligand Type Ligand Sequence
Lig153 RNA UGUGUGUGUGUG
Lig92 DNA TGTGTGTGTGTG