Heterogeneous nuclear ribonucleoprotein L

Protein information

  • Protein ID: F1LQ48
  • Protein Name : Heterogeneous nuclear ribonucleoprotein L
  • Gene : Hnrnpl
  • Organism : Rattus norvegicus
  • Status : reviewed
  • Function : Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates together with APEX1 to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827 HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).

Protein Sequence

  • MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGEGRGFPSVDSRGSCAPARRPPRKFSPVLPLFPSHPPGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
F1LQ48_RRM1 101 - 159 PF00076
F1LQ48_RRM2 181 - 267 PF11835
F1LQ48_RRM3 390 - 514 PF13893

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
F1LQ48_linker1 160 - 180
F1LQ48_linker2 268 - 389

Experiments retrieved for this Protein - 7 

Experiment ID Experiment Type PubMed ID
Exp_2MQL NMR 26051023
Exp_2MQM NMR 26051023
Exp_2MQN NMR 26051023
Exp_2MQO NMR
Exp_2MQP NMR
Exp_2MQQ NMR
Exp_4QPT X-ray Diffraction 26051023

Ligands tested for Binding - 3 

Ligand ID Ligand Type Ligand Sequence
Lig127 RNA CACACA
Lig9 RNA ACACAC
Lig157 RNA ACACA