Insulin-like growth factor 2 mRNA-binding protein 3

Protein information

  • Protein ID: O00425
  • Protein Name : Insulin-like growth factor 2 mRNA-binding protein 3
  • Gene : IGF2BP3
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.

Protein Sequence

  • MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
O00425_RRM1 4 - 69 PF00076
O00425_RRM2 83 - 150 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
O00425_linker1 70 - 82

Experiments retrieved for this Protein - 4 

Experiment ID Experiment Type PubMed ID
Exp_2E44 NMR
Exp_6FQ1 X-ray Diffraction 30135093
Exp_6FQR X-ray Diffraction 30135093
Exp_6GX6 X-ray Diffraction 30135093

Ligands tested for Binding - 3 

Ligand ID Ligand Type Ligand Sequence
Lig63 RNA CCCC
Lig75 RNA ACAC
Lig63 RNA CCCC