HIV Tat-specific factor 1

Protein information

  • Protein ID: O43719
  • Protein Name : HIV Tat-specific factor 1
  • Gene : HTATSF1
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1 it is up-regulated by the HIV-1 proteins NEF and gp120 acts as a cofactor required for the Tat-enhanced transcription of the virus.

Protein Sequence

  • MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWFPKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKAESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNLKGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKLSMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQIRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
O43719_RRM1 135 - 212 PF00076
O43719_RRM2 287 - 343 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
O43719_linker1 213 - 286

Experiments retrieved for this Protein - 8 

Experiment ID Experiment Type PubMed ID
Exp_2DIT NMR
Exp_6N3D X-ray Diffraction 30567737
Exp_6N3E X-ray Diffraction 30567737
Exp_6N3F X-ray Diffraction 30567737
Exp_6NSX X-ray Diffraction 31110137
Exp_6Y50 EM 32494006
Exp_6Y53 EM 32494006
Exp_6Y5Q EM 32494006

Ligands tested for Binding - 1 

Ligand ID Ligand Type Ligand Sequence
Lig80 RNA AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAUCUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGAAUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACGGUGCACCC