Polyadenylate-binding protein 1

Protein information

  • Protein ID: P11940
  • Protein Name : Polyadenylate-binding protein 1
  • Gene : PABPC1
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Binds the poly(A) tail of mRNA including that of its own transcript and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545 PubMed:17212783 PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545 PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299).

Protein Sequence

  • MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV

RRM domains in this Protein - 4 

RRM Entryname RRM Sequence range Pfam ID
P11940_RRM1 13 - 83 PF00076
P11940_RRM2 101 - 168 PF00076
P11940_RRM3 193 - 262 PF00076
P11940_RRM4 296 - 364 PF00076

RRM domain Linkers in this Protein - 3 

Linker Name Linker Sequence range
P11940_linker1 84 - 100
P11940_linker2 169 - 192
P11940_linker3 263 - 295

Experiments retrieved for this Protein - 6 

Experiment ID Experiment Type PubMed ID
Exp_1CVJ X-ray Diffraction 10499800
Exp_2D9P NMR
Exp_2K8G NMR
Exp_4F02 X-ray Diffraction 23041282
Exp_4F25 X-ray Diffraction 23041282
Exp_4F26 X-ray Diffraction 23041282

Ligands tested for Binding - 2 

Ligand ID Ligand Type Ligand Sequence
Lig122 RNA AAAAAAAAAAA
Lig122 RNA AAAAAAAAAAA