Transformer-2 protein homolog beta

Protein information

  • Protein ID: P62995
  • Protein Name : Transformer-2 protein homolog beta
  • Gene : TRA2B
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.

Protein Sequence

  • MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMSTRRRHVGNRANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKERANGMELDGRRIRVDFSITKRPHTPTPGIYMGRPTYGSSRRRDYYDRGYDRGYDDRDYYSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRSRSRSRSYSPRRY

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
P62995_RRM1 120 - 190 PF00076

Experiments retrieved for this Protein - 4 

Experiment ID Experiment Type PubMed ID
Exp_2CQC NMR
Exp_2KXN NMR 21399644
Exp_2RRA NMR 20926394
Exp_2RRB NMR 20926394

Ligands tested for Binding - 2 

Ligand ID Ligand Type Ligand Sequence
Lig22 RNA GAAGAA
Lig99 RNA AAGAAC