Polyadenylate-binding protein 2

Protein information

  • Protein ID: Q86U42
  • Protein Name : Polyadenylate-binding protein 2
  • Gene : PABPN1
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX which links to RNA-binding protein adapters (PubMed:27871484).

Protein Sequence

  • MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARATSWYSPY

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
Q86U42_RRM1 174 - 243 PF00076

Experiments retrieved for this Protein - 8 

Experiment ID Experiment Type PubMed ID
Exp_342 Filter binding assay 22570486
Exp_343 Filter binding assay 22570486
Exp_344 Filter binding assay 22570486
Exp_345 Filter binding assay 22570486
Exp_346 Filter binding assay 22570486
Exp_3B4D X-ray Diffraction 18275081
Exp_3B4M X-ray Diffraction 18275081
Exp_3UCG X-ray Diffraction

Ligands tested for Binding - 1 

Ligand ID Ligand Type Ligand Sequence
Lig241 RNA 32P-AAAAAAAAAAAAAA