Polypyrimidine tract-binding protein 2

Protein information

  • Protein ID: Q9UKA9
  • Protein Name : Polypyrimidine tract-binding protein 2
  • Gene : PTBP2
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing plays also a role in the regulation of translation.

Protein Sequence

  • MDGIVTEVAVGVKRGSDELLSGSVLSSPNSNMSSMVVTANGNDSKKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKTDNTLNQRAQAVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLLAVPGALSPLAIPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVSFSKSTI

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
Q9UKA9_RRM1 169 - 257 PF11835
Q9UKA9_RRM2 309 - 434 PF13893
Q9UKA9_RRM3 457 - 520 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
Q9UKA9_linker1 258 - 308
Q9UKA9_linker2 435 - 456

Experiments retrieved for this Protein - 2 

Experiment ID Experiment Type PubMed ID
Exp_2MJU NMR 24688880
Exp_4CQ1 X-ray Diffraction 24688880