P14866_RRM1

Protein information

  • Protein ID: P14866
  • Protein Name: Heterogeneous nuclear ribonucleoprotein L
  • Organism: Homo sapiens
  • Gene Name: HNRNPL

Domain information

  • Pfam ID: PF00076
  • Pfam Clan Name: RRM
  • Domain Range: 104 - 162
  • Domain Length: 59

Domain Sequence

  • VHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQI

Available Structures for this domain - 2 

Experiment ID RRM Structure Experiment Type Ligand ID Contacts
Exp_3R27 3R27B01 X-ray Diffraction No contacts
Exp_3R27 3R27A01 X-ray Diffraction No contacts

Binding Experiments for this domain - 10 

Experiment ID RRM Entryname Experiment Type Ligand ID Binds? Binding Affinity
Exp_229 P14866_RRM1 SPR Lig247 Yes 1.2 ± 0.1x0.0001 μM
Exp_231 P14866_RRM1 SPR Lig247 Yes 10 ± 1 μM
Exp_233 P14866_RRM1 SPR Lig247 Yes 0.14 ± 0.01 μM
Exp_234 P14866_RRM1 SPR Lig247 Yes 0.91 ± 0.02 μM
Exp_235 P14866_RRM1 SPR Lig247 Yes 0.2 ± 0.01 μM
Exp_236 P14866_RRM1 SPR Lig247 Yes 0.024 ± 0.001 μM
Exp_237 P14866_RRM1 SPR Lig247 Yes 0.18 ± 0.01 μM
Exp_238 P14866_RRM1 SPR Lig247 Yes 0.083 ± 0.004 μM
Exp_239 P14866_RRM1 SPR Lig247 Yes 2.3 ± 0.1 μM
Exp_240 P14866_RRM1 SPR Lig247 Yes 0.17 ± 0.01 μM

Ligands tested for Binding - 1 

Ligand ID Ligand Type Ligand Sequence
Lig247 RNA CACACAUUUUUUUUUUUUUUUUUUUUUCACACA