Q15717_RRM2

Protein information

  • Protein ID: Q15717
  • Protein Name: ELAV-like protein 1
  • Organism: Homo sapiens
  • Gene Name: ELAVL1

Domain information

  • Pfam ID: PF00076
  • Pfam Clan Name: RRM
  • Domain Range: 108 - 176
  • Domain Length: 69

Domain Sequence

  • LYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSS

Available Structures for this domain - 3 

Experiment ID RRM Structure Experiment Type Ligand ID Contacts
Exp_4ED5 4ED5B02 X-ray Diffraction Lig72 Contacts
Exp_4ED5 4ED5A02 X-ray Diffraction Lig72 Contacts
Exp_4EGL 4EGLA02 X-ray Diffraction No contacts

Binding Experiments for this domain - 7 

Experiment ID RRM Entryname Experiment Type Ligand ID Binds? Binding Affinity
Exp_292 Q15717_RRM2 SPR Lig298 Yes 33.1 ± 1.29 nM
Exp_293 Q15717_RRM2 SPR Lig249 Yes 506 ± 13.1 nM
Exp_294 Q15717_RRM2 SPR Lig298 Yes 0.05 ± 0.001 nM
Exp_295 Q15717_RRM2 SPR Lig249 Yes 0.2 ± 0.007 nM
Exp_300 Q15717_RRM2 SPR Lig152 Yes 4699 ± 116 nM
Exp_301 Q15717_RRM2 SPR Lig242 Yes 195 ± 6.3 nM
Exp_302 Q15717_RRM2 SPR Lig288 Yes 40 ± 24 nM

Ligands tested for Binding - 6 

Ligand ID Ligand Type Ligand Sequence
Lig152 RNA UUUUUUUU
Lig242 RNA UUUUUUUUUUUUU
Lig249 RNA GGGGGGUAUUUAUUAUUUAUUUAGGGGG
Lig288 RNA UUUUUUUUUUUUUUUUU
Lig298 RNA GGGGGGUUUUUUUUUUUUUUUUUGGGGG
Lig72 RNA AUUUUUAUUUU