ELAV-like protein 1

Protein information

  • Protein ID: Q15717
  • Protein Name : ELAV-like protein 1
  • Gene : ELAVL1
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288 PubMed:18285462 PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A) stabilizing them promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503 PubMed:17632515 PubMed:18285462 PubMed:23519412 PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element binds to a core element of 27 nucleotides that contain AUUUA AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010).

Protein Sequence

  • MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK

RRM domains in this Protein - 3 

RRM Entryname RRM Sequence range Pfam ID
Q15717_RRM1 22 - 92 PF00076
Q15717_RRM2 108 - 176 PF00076
Q15717_RRM3 246 - 316 PF00076

RRM domain Linkers in this Protein - 2 

Linker Name Linker Sequence range
Q15717_linker1 93 - 107
Q15717_linker2 177 - 245

Experiments retrieved for this Protein - 17 

Experiment ID Experiment Type PubMed ID
Exp_292 SPR 21233170
Exp_293 SPR 21233170
Exp_294 SPR 21233170
Exp_295 SPR 21233170
Exp_300 SPR 21233170
Exp_301 SPR 21233170
Exp_302 SPR 21233170
Exp_3HI9 X-ray Diffraction 20219472
Exp_4ED5 X-ray Diffraction 23519412
Exp_4EGL X-ray Diffraction
Exp_4FXV X-ray Diffraction
Exp_5SZW NMR 30535889
Exp_6G2K X-ray Diffraction 30418581
Exp_6GC5 X-ray Diffraction 30718402
Exp_6GD1 X-ray Diffraction 30418581
Exp_6GD2 X-ray Diffraction 30418581
Exp_6GD3 X-ray Diffraction 30418581

Ligands tested for Binding - 18 

Ligand ID Ligand Type Ligand Sequence
Lig152 RNA UUUUUUUU
Lig242 RNA UUUUUUUUUUUUU
Lig249 RNA GGGGGGUAUUUAUUAUUUAUUUAGGGGG
Lig288 RNA UUUUUUUUUUUUUUUUU
Lig298 RNA GGGGGGUUUUUUUUUUUUUUUUUGGGGG
Lig72 RNA AUUUUUAUUUU
Lig152 RNA UUUUUUUU
Lig242 RNA UUUUUUUUUUUUU
Lig249 RNA GGGGGGUAUUUAUUAUUUAUUUAGGGGG
Lig288 RNA UUUUUUUUUUUUUUUUU
Lig298 RNA GGGGGGUUUUUUUUUUUUUUUUUGGGGG
Lig72 RNA AUUUUUAUUUU
Lig196 RNA AUUUUUAUUUUAUUU
Lig249 RNA GGGGGGUAUUUAUUAUUUAUUUAGGGGG
Lig298 RNA GGGGGGUUUUUUUUUUUUUUUUUGGGGG
Lig46 RNA UUUUUU
Lig72 RNA AUUUUUAUUUU
Lig77 RNA UAUUUA