Q920Q6_RRM2

Protein information

  • Protein ID: Q920Q6
  • Protein Name: RNA-binding protein Musashi homolog 2
  • Organism: Mus musculus
  • Gene Name: Msi2

Domain information

  • Pfam ID: PF00076
  • Pfam Clan Name: RRM
  • Domain Range: 112 - 181
  • Domain Length: 70

Domain Sequence

  • IFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVE

Binding Experiments for this domain - 37 

Experiment ID RRM Entryname Experiment Type Ligand ID Binds? Binding Affinity
Exp_105 Q920Q6_RRM2 Fluorescence polarization Lig274 Yes 28 ± 4.0 nM
Exp_106 Q920Q6_RRM2 Fluorescence polarization Lig332 Yes 22.2 ± 1.4 nM
Exp_107 Q920Q6_RRM2 Fluorescence polarization Lig291 Yes 28.3 ± 1.0 nM
Exp_108 Q920Q6_RRM2 Fluorescence polarization Lig256 Yes 20.8 ± 1.2 nM
Exp_109 Q920Q6_RRM2 Fluorescence polarization Lig245 Yes 29.8 ± 1.2 nM
Exp_110 Q920Q6_RRM2 Fluorescence polarization Lig263 Yes 27 ± 0.6 nM
Exp_111 Q920Q6_RRM2 Fluorescence polarization Lig289 Yes 16.3 ± 0.7 nM
Exp_112 Q920Q6_RRM2 Fluorescence polarization Lig229 Yes 54.8 ± 1.7 nM
Exp_113 Q920Q6_RRM2 Fluorescence polarization Lig268 Yes 85.9 ± 2.1 nM
Exp_114 Q920Q6_RRM2 Fluorescence polarization Lig266 Yes 55.1 ± 2.0 nM
Exp_115 Q920Q6_RRM2 Fluorescence polarization Lig248 Yes 74.5 ± 1.0 nM
Exp_116 Q920Q6_RRM2 Fluorescence polarization Lig239 Yes 33.3 ± 1.3 nM
Exp_117 Q920Q6_RRM2 Fluorescence polarization Lig334 Yes 49.7 ± 2.2 nM
Exp_118 Q920Q6_RRM2 Fluorescence polarization Lig236 Yes 446 ± 108.3 nM
Exp_119 Q920Q6_RRM2 Fluorescence polarization Lig271 Yes 178.7 ± 6.6 nM
Exp_120 Q920Q6_RRM2 Fluorescence polarization Lig297 Yes 57.1 ± 4.9 nM
Exp_121 Q920Q6_RRM2 Fluorescence polarization Lig230 Yes 292.3 ± 45.5 nM
Exp_122 Q920Q6_RRM2 Fluorescence polarization Lig277 Yes 468 ± 72.1 nM
Exp_123 Q920Q6_RRM2 Fluorescence polarization Lig323 Yes 297.7 ± 36.0 nM
Exp_124 Q920Q6_RRM2 Fluorescence polarization Lig264 Yes 337.7 ± 35.0 nM
Exp_125 Q920Q6_RRM2 Fluorescence polarization Lig251 Yes 352.3 ± 41.1 nM
Exp_126 Q920Q6_RRM2 Fluorescence polarization Lig294 Yes 468.7 ± 45.6 nM
Exp_127 Q920Q6_RRM2 Fluorescence polarization Lig269 Yes 44.4 ± 0.6 nM
Exp_128 Q920Q6_RRM2 Fluorescence polarization Lig224 Yes 50.9 ± 0.2 nM
Exp_129 Q920Q6_RRM2 Fluorescence polarization Lig324 Yes 23.3 ± 2.2 nM
Exp_130 Q920Q6_RRM2 Fluorescence polarization Lig283 Yes 33.6 ± 1.6 nM
Exp_131 Q920Q6_RRM2 Fluorescence polarization Lig327 Yes 25.8 ± 1.4 nM
Exp_132 Q920Q6_RRM2 Fluorescence polarization Lig313 Yes 25.1 ± 0.4 nM
Exp_133 Q920Q6_RRM2 Fluorescence polarization Lig243 Yes 28.1 ± 0.7 nM
Exp_134 Q920Q6_RRM2 Fluorescence polarization Lig306 Yes 28.7 ± 0.6 nM
Exp_135 Q920Q6_RRM2 Fluorescence polarization Lig310 Yes 24.8 ± 2.5 nM
Exp_136 Q920Q6_RRM2 Fluorescence polarization Lig227 Yes 26.2 ± 0.2 nM
Exp_137 Q920Q6_RRM2 Fluorescence polarization Lig260 Yes 28.5 ± 0.4 nM
Exp_138 Q920Q6_RRM2 Fluorescence polarization Lig262 Yes 20.2 ± 1.1 nM
Exp_139 Q920Q6_RRM2 Fluorescence polarization Lig273 Yes 28 ± 0.6 nM
Exp_140 Q920Q6_RRM2 Fluorescence polarization Lig265 Yes 27.1 ± 0.5 nM
Exp_141 Q920Q6_RRM2 Fluorescence polarization Lig252 Yes 20.6 ± 1.7 nM

Ligands tested for Binding - 37 

Ligand ID Ligand Type Ligand Sequence
Lig224 RNA UUUAUAGCUUUU
Lig227 RNA UUUAUAGUUUAU
Lig229 RNA UUAAUAGUUUUU
Lig230 RNA UUUAUCGUUUUU
Lig236 RNA UUUAAAGUUUUU
Lig239 RNA UUUGUAGUUUUU
Lig243 RNA UUUAUAGUUAUU
Lig245 RNA UAUAUAGUUUUU
Lig248 RNA UUUCUAGUUUUU
Lig251 RNA UUUAUACUUUUU
Lig252 RNA UUUAUAGUUUUG
Lig256 RNA GUUAUAGUUUUU
Lig260 RNA UUUAUAGUUUCU
Lig262 RNA UUUAUAGUUUGU
Lig263 RNA UCUAUAGUUUUU
Lig264 RNA UUUAUAAUUUUU
Lig265 RNA UUUAUAGUUUUC
Lig266 RNA UUGAUAGUUUUU
Lig268 RNA UUCAUAGUUUUU
Lig269 RNA UUUAUAGAUUUU
Lig271 RNA UUUACAGUUUUU
Lig273 RNA UUUAUAGUUUUA
Lig274 RNA UUUAUAGUUUUU
Lig277 RNA UUUAUGGUUUUU
Lig283 RNA UUUAUAGUAUUU
Lig289 RNA UGUAUAGUUUUU
Lig291 RNA CUUAUAGUUUUU
Lig294 RNA UUUAUAUUUUUU
Lig297 RNA UUUAGAGUUUUU
Lig306 RNA UUUAUAGUUCUU
Lig310 RNA UUUAUAGUUGUU
Lig313 RNA UUUAUAGUGUUU
Lig323 RNA UUUAUUGUUUUU
Lig324 RNA UUUAUAGGUUUU
Lig327 RNA UUUAUAGUCUUU
Lig332 RNA AUUAUAGUUUUU
Lig334 RNA UUUUUAGUUUUU