U1 small nuclear ribonucleoprotein 70 kDa

Protein information

  • Protein ID: P08621
  • Protein Name : U1 small nuclear ribonucleoprotein 70 kDa
  • Gene : SNRNP70
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Component of the spliceosomal U1 snRNP which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628 PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746 PubMed:19325628 PubMed:25555158).

Protein Sequence

  • MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLEGLGNDSRDMYMESEGGDGYLAPENGYLMEAAPE

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
P08621_RRM1 105 - 175 PF00076

Experiments retrieved for this Protein - 5 

Experiment ID Experiment Type PubMed ID
Exp_3CW1 X-ray Diffraction 19325628
Exp_3PGW X-ray Diffraction 21113136
Exp_4PKD X-ray Diffraction 25555158
Exp_6QX9 EM 30975767
Exp_7B0Y EM 33446560

Ligands tested for Binding - 2 

Ligand ID Ligand Type Ligand Sequence
Lig179 RNA GGAUCCAUUGCACUCCGGAUCCAGGAGAUACCAUGAUCACGAAGGUGGUUUUCCU
Lig42 RNA AUACUUACCUGGCAGGGGAGAUACCAUGAUCACGAAGGUGGUUUUCCCAGGGCGAGGCUUAUCCAUUGCACUCCGGAUGUGCUGACCCCUGCGAUUUCCCCAAAUGUGGGAAACUCGACUGCAUAAUUUGUGGUAGUGGGGGACUGCGUUCGCGCUUUCCCCUG