P31483_RRM2

Protein information

  • Protein ID: P31483
  • Protein Name: Cytotoxic granule associated RNA binding protein TIA1
  • Organism: Homo sapiens
  • Gene Name: TIA1

Domain information

  • Pfam ID: PF00076
  • Pfam Clan Name: RRM
  • Domain Range: 108 - 178
  • Domain Length: 71

Domain Sequence

  • VFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIR

Available Structures for this domain - 5 

Experiment ID RRM Structure Experiment Type Ligand ID Contacts
Exp_2MJN 2MJNA01 NMR No contacts
Exp_3BS9 3BS9B01 X-ray Diffraction No contacts
Exp_3BS9 3BS9A01 X-ray Diffraction No contacts
Exp_5ITH 5ITHA01 X-ray Diffraction Lig193 Contacts
Exp_5O3J 5O3JA01 X-ray Diffraction Lig204 Contacts

Binding Experiments for this domain - 20 

Experiment ID RRM Entryname Experiment Type Ligand ID Binds? Binding Affinity
Exp_216 P31483_RRM2 ITC Lig255 Yes 0.4 ± 0.1 nM
Exp_217 P31483_RRM2 ITC Lig255 Yes 272.5 ± 14.9 nM
Exp_218 P31483_RRM2 ITC Lig255 Yes 216 ± 47.6 nM
Exp_219 P31483_RRM2 ITC Lig15 Yes 7 ± 0.2 nM
Exp_220 P31483_RRM2 ITC Lig15 Yes 5.6 ± 1.9 nM
Exp_221 P31483_RRM2 ITC Lig286 Yes 35.6 ± 8.1 nM
Exp_222 P31483_RRM2 ITC Lig325 Yes 16.9 ± 2.7 nM
Exp_223 P31483_RRM2 Fluorescence polarization Lig339 Yes 0.13 ± 0.007 μM
Exp_224 P31483_RRM2 Fluorescence polarization Lig339 Yes 6.6 ± 0.7 μM
Exp_225 P31483_RRM2 Fluorescence polarization Lig339 Yes 0.13 ± 0.01 μM
Exp_226 P31483_RRM2 Fluorescence polarization Lig307 Yes 0.14 ± 0.03 μM
Exp_227 P31483_RRM2 Fluorescence polarization Lig339 Yes 9.1 ± 2 μM
Exp_228 P31483_RRM2 Fluorescence polarization Lig319 Yes 0.005 ± 0.0003 μM
Exp_308 P31483_RRM2 CD Spectroscopy Lig226 Yes 4.4 ± 0.4 nM
Exp_309 P31483_RRM2 CD Spectroscopy Lig226 Yes 58.5 ± 6 nM
Exp_359 P31483_RRM2 Fluorescence polarization Lig193 Yes 0.09 ± 0.005 μM
Exp_360 P31483_RRM2 Fluorescence polarization Lig193 Yes 5.1 ± 0.6 μM
Exp_361 P31483_RRM2 Fluorescence polarization Lig193 Yes 0.03 ± 0.003 μM
Exp_362 P31483_RRM2 Fluorescence polarization Lig285 Yes 0.05 ± 0.05 μM
Exp_363 P31483_RRM2 Fluorescence polarization Lig304 Yes 0.008 ± 0.001 μM

Ligands tested for Binding - 12 

Ligand ID Ligand Type Ligand Sequence
Lig15 RNA UUUUUUUUU
Lig193 DNA ACTCCTTTTT
Lig204 RNA UUC
Lig226 RNA AUUUAUUUAUUUAUUUAUUUAUUU
Lig255 RNA GUUAUAUUCUCCUUUC
Lig285 DNA ATTCTCCTTT
Lig286 RNA UUCUCCUUUC
Lig304 DNA TTTTTACTCC
Lig307 RNA AUUCUCCUUU
Lig319 RNA UUUUUACUCC
Lig325 RNA UUUUUUUUUUUUUUU
Lig339 RNA ACUCCUUUUU