Lig15

Ligand information

  • Ligand ID: Lig15
  • Ligand Type : RNA
  • Ligand Length : 9
  • Ligand Sequence : UUUUUUUUU

Available Structures for this Ligand- 2

Ligand Structurename PDB ID Chain ID
2YH1B00 2YH1 B
5EV1B00 5EV1 B

Binding Information from Structures

Experiment ID RRM Structure RRM Entryename Experiment Type Ligand ID Contacts
Exp_2YH1 2YH1A01 P26368_RRM1 NMR Lig15 Contacts
Exp_2YH1 2YH1A02 P26368_RRM2 NMR Lig15 Contacts
Exp_5EV1 5EV1A01 P26368_RRM1 X-ray Diffraction Lig15 Contacts
Exp_5EV1 5EV1A02 P26368_RRM2 X-ray Diffraction Lig15 Contacts

Binding Experiments for this domain - 4 

Experiment ID RRM Entryname Experiment Type Ligand ID Binds? Binding Affinity
Exp_219 P31483_RRM3 ITC Lig15 Yes 7 ± 0.2 nM
Exp_219 P31483_RRM2 ITC Lig15 Yes 7 ± 0.2 nM
Exp_220 P31483_RRM3 ITC Lig15 Yes 5.6 ± 1.9 nM
Exp_220 P31483_RRM2 ITC Lig15 Yes 5.6 ± 1.9 nM

RRM domains tested for Binding - 4 

RRM Entryname Sequence Range RRM Sequence
P26368_RRM1 151 - 225 LYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLK
P26368_RRM2 261 - 331 LFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLL
P31483_RRM2 108 - 178 VFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIR
P31483_RRM3 216 - 280 VYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVK