Q01130_RRM1

Protein information

  • Protein ID: Q01130
  • Protein Name: Serine/arginine-rich splicing factor 2
  • Organism: Homo sapiens
  • Gene Name: SRSF2

Domain information

  • Pfam ID: PF00076
  • Pfam Clan Name: RRM
  • Domain Range: 16 - 86
  • Domain Length: 71

Domain Sequence

  • LKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELR

Available Structures for this domain - 4 

Experiment ID RRM Structure Experiment Type Ligand ID Contacts
Exp_2KN4 2KN4A01 NMR No contacts
Exp_2LEA 2LEAA01 NMR No contacts
Exp_2LEB 2LEBA01 NMR Lig161 Contacts
Exp_2LEC 2LECA01 NMR Lig221 Contacts

Binding Experiments for this domain - 35 

Experiment ID RRM Entryname Experiment Type Ligand ID Binds? Binding Affinity
Exp_364 Q01130_RRM1 ITC Lig161 Yes 0.27 ± 0.02 μM
Exp_365 Q01130_RRM1 ITC Lig221 Yes 0.22 ± 0.03 μM
Exp_366 Q01130_RRM1 ITC Lig161 Yes 2.38 ± 0.38 μM
Exp_367 Q01130_RRM1 ITC Lig221 Yes 2.8 ± 0.1 μM
Exp_368 Q01130_RRM1 ITC Lig161 Yes 4.09 ± 0.58 μM
Exp_369 Q01130_RRM1 ITC Lig221 Yes 3.7 ± 0.8 μM
Exp_370 Q01130_RRM1 ITC Lig161 Yes 5 ± μM
Exp_371 Q01130_RRM1 ITC Lig221 Yes 5 ± μM
Exp_372 Q01130_RRM1 ITC Lig161 Yes 0.83 ± μM
Exp_373 Q01130_RRM1 ITC Lig221 Yes 0.6 ± μM
Exp_374 Q01130_RRM1 ITC Lig161 Yes 0.37 ± μM
Exp_375 Q01130_RRM1 ITC Lig161 No
Exp_376 Q01130_RRM1 ITC Lig221 No
Exp_377 Q01130_RRM1 ITC Lig161 Yes 5 ± μM
Exp_378 Q01130_RRM1 ITC Lig221 Yes 5 ± μM
Exp_379 Q01130_RRM1 ITC Lig221 Yes 0.46 ± μM
Exp_380 Q01130_RRM1 ITC Lig161 Yes 0.35 ± μM
Exp_381 Q01130_RRM1 ITC Lig221 Yes 0.23 ± μM
Exp_382 Q01130_RRM1 ITC Lig161 Yes 0.6 ± 0.05 μM
Exp_383 Q01130_RRM1 ITC Lig221 Yes 0.86 ± 0.04 μM
Exp_384 Q01130_RRM1 ITC Lig161 Yes 1.1 ± 0.02 μM
Exp_385 Q01130_RRM1 ITC Lig221 Yes 4.4 ± 0.0 μM
Exp_386 Q01130_RRM1 ITC Lig345 Yes 0.47 ± 0.02 μM
Exp_387 Q01130_RRM1 ITC Lig346 Yes 0.41 ± 0.03 μM
Exp_388 Q01130_RRM1 ITC Lig347 Yes 1.92 ± 0.06 μM
Exp_389 Q01130_RRM1 ITC Lig348 Yes 2.7 ± 0.1 μM
Exp_390 Q01130_RRM1 ITC Lig349 Yes 5.2 ± 0.38 μM
Exp_391 Q01130_RRM1 ITC Lig350 Yes 0.36 ± 0.02 μM
Exp_392 Q01130_RRM1 ITC Lig351 Yes 6.4 ± 0.2 μM
Exp_393 Q01130_RRM1 ITC Lig352 Yes 0.36 ± 0.02 μM
Exp_394 Q01130_RRM1 ITC Lig353 Yes 0.34 ± 0.04 μM
Exp_395 Q01130_RRM1 ITC Lig354 Yes 0.39 ± 0.03 μM
Exp_396 Q01130_RRM1 ITC Lig355 Yes 7.6 ± 1.4 μM
Exp_397 Q01130_RRM1 ITC Lig356 Yes 17.2 ± 3 μM
Exp_398 Q01130_RRM1 ITC Lig357 Yes 11.4 ± 1 μM

Ligands tested for Binding - 15 

Ligand ID Ligand Type Ligand Sequence
Lig353 RNA UCCGGU
Lig351 RNA UCUAGU
Lig356 RNA UCCACU
Lig161 RNA UCCAGU
Lig349 RNA UCAAGU
Lig348 RNA UUCAGU
Lig355 RNA UCCAAU
Lig354 RNA UCCCGU
Lig345 RNA CCCAGU
Lig352 RNA UCCUGU
Lig357 RNA UCCAUU
Lig347 RNA UACAGU
Lig350 RNA UCGAGU
Lig221 RNA UGGAGU
Lig346 RNA UGCAGU