Q13148_RRM1

Protein information

  • Protein ID: Q13148
  • Protein Name: TAR DNA-binding protein 43
  • Organism: Homo sapiens
  • Gene Name: TARDBP

Domain information

  • Pfam ID: PF00076
  • Pfam Clan Name: RRM
  • Domain Range: 106 - 172
  • Domain Length: 67

Domain Sequence

  • LIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRW

Available Structures for this domain - 9 

Experiment ID RRM Structure Experiment Type Ligand ID Contacts
Exp_2CQG 2CQGA01 NMR No contacts
Exp_4BS2 4BS2A01 NMR Lig121 Contacts
Exp_4IUF 4IUFA01 X-ray Diffraction Lig79 Contacts
Exp_4Y00 4Y00D01 X-ray Diffraction Lig106 Contacts
Exp_4Y00 4Y00C01 X-ray Diffraction Lig106 Contacts
Exp_4Y00 4Y00B01 X-ray Diffraction Lig106 Contacts
Exp_4Y00 4Y00A01 X-ray Diffraction Lig106 Contacts
Exp_4Y0F 4Y0FB01 X-ray Diffraction Lig106 Contacts
Exp_4Y0F 4Y0FA01 X-ray Diffraction Lig106 Contacts

Binding Experiments for this domain - 19 

Experiment ID RRM Entryname Experiment Type Ligand ID Binds? Binding Affinity
Exp_310 Q13148_RRM1 ITC Lig296 Yes 22.6 ± 6.2 nM
Exp_311 Q13148_RRM1 ITC Lig121 Yes 26.9 ± 4.3 nM
Exp_312 Q13148_RRM1 ITC Lig261 Yes 33.2 ± 4.4 nM
Exp_313 Q13148_RRM1 ITC Lig340 Yes 32.4 ± 5.9 nM
Exp_314 Q13148_RRM1 ITC Lig272 Yes 70 ± 9.6 nM
Exp_315 Q13148_RRM1 ITC Lig121 Yes 85.5 ± 14.8 nM
Exp_316 Q13148_RRM1 ITC Lig121 Yes 529.1 ± 26.1 nM
Exp_317 Q13148_RRM1 ITC Lig121 Yes 155.8 ± 9.6 nM
Exp_318 Q13148_RRM1 ITC Lig121 Yes 393.7 ± 15.8 nM
Exp_319 Q13148_RRM1 ITC Lig121 Yes 471.7 ± 36.5 nM
Exp_320 Q13148_RRM1 ITC Lig121 Yes 109.4 ± 13.4 nM
Exp_321 Q13148_RRM1 ITC Lig121 Yes 27.5 ± 4.3 nM
Exp_322 Q13148_RRM1 ITC Lig121 Yes 122.1 ± 8.3 nM
Exp_323 Q13148_RRM1 ITC Lig121 Yes 35.6 ± 7.9 nM
Exp_324 Q13148_RRM1 ITC Lig121 Yes 64.9 ± 9.2 nM
Exp_325 Q13148_RRM1 ITC Lig121 Yes 28.8 ± 3.4 nM
Exp_326 Q13148_RRM1 ITC Lig121 Yes 1000 ± nM
Exp_327 Q13148_RRM1 ITC Lig121 Yes 191.9 ± 21.7 nM
Exp_328 Q13148_RRM1 ITC Lig121 Yes 66.7 ± 7.9 nM

Ligands tested for Binding - 7 

Ligand ID Ligand Type Ligand Sequence
Lig106 DNA GTTGAGCGTT
Lig121 RNA GUGUGAAUGAAU
Lig261 RNA GUGUGAUGAAU
Lig272 RNA GUGUGUGAAUGAAU
Lig296 RNA GUGUGUGUGUGU
Lig340 RNA GUGUGUGUGAAU
Lig79 DNA GTTGAGCGT