RNA-binding protein Musashi homolog 1

Protein information

  • Protein ID: Q61474
  • Protein Name : RNA-binding protein Musashi homolog 1
  • Gene : Msi1
  • Organism : Mus musculus
  • Status : reviewed
  • Function : RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.

Protein Sequence

  • METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKHYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERSPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNGYH

RRM domains in this Protein - 2 

RRM Entryname RRM Sequence range Pfam ID
Q61474_RRM1 22 - 91 PF00076
Q61474_RRM2 111 - 180 PF00076

RRM domain Linkers in this Protein - 1 

Linker Name Linker Sequence range
Q61474_linker1 92 - 110

Experiments retrieved for this Protein - 88 

Experiment ID Experiment Type PubMed ID
Exp_23 Fluorescence polarization 25368328
Exp_24 Fluorescence polarization 25368328
Exp_25 Fluorescence polarization 25368328
Exp_26 Fluorescence polarization 25368328
Exp_27 Fluorescence polarization 25368328
Exp_28 Fluorescence polarization 25368328
Exp_29 Fluorescence polarization 25368328
Exp_30 Fluorescence polarization 25368328
Exp_31 Fluorescence polarization 25368328
Exp_32 Fluorescence polarization 25368328
Exp_33 Fluorescence polarization 25368328
Exp_34 Fluorescence polarization 25368328
Exp_35 Fluorescence polarization 25368328
Exp_36 Fluorescence polarization 25368328
Exp_37 Fluorescence polarization 25368328
Exp_38 Fluorescence polarization 25368328
Exp_39 Fluorescence polarization 25368328
Exp_40 Fluorescence polarization 25368328
Exp_41 Fluorescence polarization 25368328
Exp_42 Fluorescence polarization 25368328
Exp_43 Fluorescence polarization 25368328
Exp_44 Fluorescence polarization 25368328
Exp_45 Fluorescence polarization 25368328
Exp_46 Fluorescence polarization 25368328
Exp_47 Fluorescence polarization 25368328
Exp_48 Fluorescence polarization 25368328
Exp_49 Fluorescence polarization 25368328
Exp_50 Fluorescence polarization 25368328
Exp_51 Fluorescence polarization 25368328
Exp_52 Fluorescence polarization 25368328
Exp_53 Fluorescence polarization 25368328
Exp_54 Fluorescence polarization 25368328
Exp_55 Fluorescence polarization 25368328
Exp_56 Fluorescence polarization 25368328
Exp_57 Fluorescence polarization 25368328
Exp_58 Fluorescence polarization 25368328
Exp_59 Fluorescence polarization 25368328
Exp_60 Fluorescence polarization 25368328
Exp_61 Fluorescence polarization 25368328
Exp_62 Fluorescence polarization 25368328
Exp_63 Fluorescence polarization 25368328
Exp_64 Fluorescence polarization 25368328
Exp_65 Fluorescence polarization 25368328
Exp_66 Fluorescence polarization 25368328
Exp_67 Fluorescence polarization 25368328
Exp_68 Fluorescence polarization 25368328
Exp_69 Fluorescence polarization 25368328
Exp_70 Fluorescence polarization 25368328
Exp_71 Fluorescence polarization 25368328
Exp_72 Fluorescence polarization 25368328
Exp_73 Fluorescence polarization 25368328
Exp_74 Fluorescence polarization 25368328
Exp_75 Fluorescence polarization 25368328
Exp_76 Fluorescence polarization 25368328
Exp_77 Fluorescence polarization 25368328
Exp_78 Fluorescence polarization 25368328
Exp_79 Fluorescence polarization 25368328
Exp_80 Fluorescence polarization 25368328
Exp_81 Fluorescence polarization 25368328
Exp_82 Fluorescence polarization 25368328
Exp_83 Fluorescence polarization 25368328
Exp_84 Fluorescence polarization 25368328
Exp_85 Fluorescence polarization 25368328
Exp_86 Fluorescence polarization 25368328
Exp_87 Fluorescence polarization 25368328
Exp_88 Fluorescence polarization 25368328
Exp_89 Fluorescence polarization 25368328
Exp_90 Fluorescence polarization 25368328
Exp_91 Fluorescence polarization 25368328
Exp_92 Fluorescence polarization 25368328
Exp_93 Fluorescence polarization 25368328
Exp_94 Fluorescence polarization 25368328
Exp_95 Fluorescence polarization 25368328
Exp_96 Fluorescence polarization 25368328
Exp_97 Fluorescence polarization 25368328
Exp_98 Fluorescence polarization 25368328
Exp_99 Fluorescence polarization 25368328
Exp_100 Fluorescence polarization 25368328
Exp_101 Fluorescence polarization 25368328
Exp_102 Fluorescence polarization 25368328
Exp_103 Fluorescence polarization 25368328
Exp_104 Fluorescence polarization 25368328
Exp_1UAW NMR 12907678
Exp_2MSS NMR 10080895
Exp_2MST NMR 10080895
Exp_2RS2 NMR 22140116
Exp_5X3Y NMR 28753936
Exp_5X3Z NMR 28753936

Ligands tested for Binding - 92 

Ligand ID Ligand Type Ligand Sequence
Lig166 RNA GUAGU
Lig224 RNA UUUAUAGCUUUU
Lig227 RNA UUUAUAGUUUAU
Lig229 RNA UUAAUAGUUUUU
Lig230 RNA UUUAUCGUUUUU
Lig236 RNA UUUAAAGUUUUU
Lig239 RNA UUUGUAGUUUUU
Lig240 RNA UUUAUUUUUAGUUUUU
Lig243 RNA UUUAUAGUUAUU
Lig245 RNA UAUAUAGUUUUU
Lig248 RNA UUUCUAGUUUUU
Lig251 RNA UUUAUACUUUUU
Lig252 RNA UUUAUAGUUUUG
Lig256 RNA GUUAUAGUUUUU
Lig260 RNA UUUAUAGUUUCU
Lig262 RNA UUUAUAGUUUGU
Lig263 RNA UCUAUAGUUUUU
Lig264 RNA UUUAUAAUUUUU
Lig265 RNA UUUAUAGUUUUC
Lig266 RNA UUGAUAGUUUUU
Lig268 RNA UUCAUAGUUUUU
Lig269 RNA UUUAUAGAUUUU
Lig271 RNA UUUACAGUUUUU
Lig273 RNA UUUAUAGUUUUA
Lig274 RNA UUUAUAGUUUUU
Lig277 RNA UUUAUGGUUUUU
Lig280 RNA UUCAUUAGUUUUU
Lig283 RNA UUUAUAGUAUUU
Lig289 RNA UGUAUAGUUUUU
Lig291 RNA CUUAUAGUUUUU
Lig292 RNA UUUAUUAGUUUUU
Lig294 RNA UUUAUAUUUUUU
Lig297 RNA UUUAGAGUUUUU
Lig302 RNA UUCAUUUUAGUUUUU
Lig303 RNA UUCAUUUAGUUUUU
Lig306 RNA UUUAUAGUUCUU
Lig308 RNA UUUAUUUAGUUUUU
Lig310 RNA UUUAUAGUUGUU
Lig313 RNA UUUAUAGUGUUU
Lig323 RNA UUUAUUGUUUUU
Lig324 RNA UUUAUAGGUUUU
Lig327 RNA UUUAUAGUCUUU
Lig330 RNA UUUAUUUUAGUUUUU
Lig332 RNA AUUAUAGUUUUU
Lig334 RNA UUUUUAGUUUUU
Lig341 RNA UUCAUUUUUAGUUUUU
Lig166 RNA GUAGU
Lig224 RNA UUUAUAGCUUUU
Lig227 RNA UUUAUAGUUUAU
Lig229 RNA UUAAUAGUUUUU
Lig230 RNA UUUAUCGUUUUU
Lig236 RNA UUUAAAGUUUUU
Lig239 RNA UUUGUAGUUUUU
Lig240 RNA UUUAUUUUUAGUUUUU
Lig243 RNA UUUAUAGUUAUU
Lig245 RNA UAUAUAGUUUUU
Lig248 RNA UUUCUAGUUUUU
Lig251 RNA UUUAUACUUUUU
Lig252 RNA UUUAUAGUUUUG
Lig256 RNA GUUAUAGUUUUU
Lig260 RNA UUUAUAGUUUCU
Lig262 RNA UUUAUAGUUUGU
Lig263 RNA UCUAUAGUUUUU
Lig264 RNA UUUAUAAUUUUU
Lig265 RNA UUUAUAGUUUUC
Lig266 RNA UUGAUAGUUUUU
Lig268 RNA UUCAUAGUUUUU
Lig269 RNA UUUAUAGAUUUU
Lig271 RNA UUUACAGUUUUU
Lig273 RNA UUUAUAGUUUUA
Lig274 RNA UUUAUAGUUUUU
Lig277 RNA UUUAUGGUUUUU
Lig280 RNA UUCAUUAGUUUUU
Lig283 RNA UUUAUAGUAUUU
Lig289 RNA UGUAUAGUUUUU
Lig291 RNA CUUAUAGUUUUU
Lig292 RNA UUUAUUAGUUUUU
Lig294 RNA UUUAUAUUUUUU
Lig297 RNA UUUAGAGUUUUU
Lig302 RNA UUCAUUUUAGUUUUU
Lig303 RNA UUCAUUUAGUUUUU
Lig306 RNA UUUAUAGUUCUU
Lig308 RNA UUUAUUUAGUUUUU
Lig310 RNA UUUAUAGUUGUU
Lig313 RNA UUUAUAGUGUUU
Lig323 RNA UUUAUUGUUUUU
Lig324 RNA UUUAUAGGUUUU
Lig327 RNA UUUAUAGUCUUU
Lig330 RNA UUUAUUUUAGUUUUU
Lig332 RNA AUUAUAGUUUUU
Lig334 RNA UUUUUAGUUUUU
Lig341 RNA UUCAUUUUUAGUUUUU