Q61474_RRM1

Protein information

  • Protein ID: Q61474
  • Protein Name: RNA-binding protein Musashi homolog 1
  • Organism: Mus musculus
  • Gene Name: Msi1

Domain information

  • Pfam ID: PF00076
  • Pfam Clan Name: RRM
  • Domain Range: 22 - 91
  • Domain Length: 70

Domain Sequence

  • MFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTID

Available Structures for this domain - 2 

Experiment ID RRM Structure Experiment Type Ligand ID Contacts
Exp_1UAW 1UAWA01 NMR No contacts
Exp_2RS2 2RS2A01 NMR Lig166 Contacts

Binding Experiments for this domain - 82 

Experiment ID RRM Entryname Experiment Type Ligand ID Binds? Binding Affinity
Exp_23 Q61474_RRM1 Fluorescence polarization Lig274 Yes 21 ± 1.0 nM
Exp_24 Q61474_RRM1 Fluorescence polarization Lig332 Yes 17.7 ± 0.4 nM
Exp_25 Q61474_RRM1 Fluorescence polarization Lig291 Yes 22.4 ± 1.3 nM
Exp_26 Q61474_RRM1 Fluorescence polarization Lig256 Yes 16.1 ± 1.3 nM
Exp_27 Q61474_RRM1 Fluorescence polarization Lig245 Yes 28 ± 0.4 nM
Exp_28 Q61474_RRM1 Fluorescence polarization Lig263 Yes 23 ± 0.8 nM
Exp_29 Q61474_RRM1 Fluorescence polarization Lig289 Yes 17.6 ± 1.6 nM
Exp_30 Q61474_RRM1 Fluorescence polarization Lig229 Yes 42.7 ± 1.9 nM
Exp_31 Q61474_RRM1 Fluorescence polarization Lig268 Yes 67.4 ± 3.5 nM
Exp_32 Q61474_RRM1 Fluorescence polarization Lig266 Yes 42.6 ± 2.0 nM
Exp_33 Q61474_RRM1 Fluorescence polarization Lig248 Yes 51.1 ± 1.4 nM
Exp_34 Q61474_RRM1 Fluorescence polarization Lig239 Yes 23.6 ± 0.4 nM
Exp_35 Q61474_RRM1 Fluorescence polarization Lig334 Yes 41.1 ± 1.7 nM
Exp_36 Q61474_RRM1 Fluorescence polarization Lig236 Yes 294.3 ± 23.0 nM
Exp_37 Q61474_RRM1 Fluorescence polarization Lig271 Yes 157 ± 5.6 nM
Exp_38 Q61474_RRM1 Fluorescence polarization Lig297 Yes 46.9 ± 4.5 nM
Exp_39 Q61474_RRM1 Fluorescence polarization Lig230 Yes 230.7 ± 7.5 nM
Exp_40 Q61474_RRM1 Fluorescence polarization Lig277 Yes 230.3 ± 5.0 nM
Exp_41 Q61474_RRM1 Fluorescence polarization Lig323 Yes 268.3 ± 24.4 nM
Exp_42 Q61474_RRM1 Fluorescence polarization Lig264 Yes 306.3 ± 16.0 nM
Exp_43 Q61474_RRM1 Fluorescence polarization Lig251 Yes 366 ± 7.2 nM
Exp_44 Q61474_RRM1 Fluorescence polarization Lig294 Yes 351.7 ± 36.0 nM
Exp_45 Q61474_RRM1 Fluorescence polarization Lig269 Yes 37.7 ± 0.5 nM
Exp_46 Q61474_RRM1 Fluorescence polarization Lig224 Yes 42.8 ± 0.2 nM
Exp_47 Q61474_RRM1 Fluorescence polarization Lig324 Yes 21.6 ± 0.9 nM
Exp_48 Q61474_RRM1 Fluorescence polarization Lig283 Yes 30 ± 0.7 nM
Exp_49 Q61474_RRM1 Fluorescence polarization Lig327 Yes 23.3 ± 0.6 nM
Exp_50 Q61474_RRM1 Fluorescence polarization Lig313 Yes 22.6 ± 1.3 nM
Exp_51 Q61474_RRM1 Fluorescence polarization Lig243 Yes 19.6 ± 1.0 nM
Exp_52 Q61474_RRM1 Fluorescence polarization Lig306 Yes 26.8 ± 2.9 nM
Exp_53 Q61474_RRM1 Fluorescence polarization Lig310 Yes 21.2 ± 1.6 nM
Exp_54 Q61474_RRM1 Fluorescence polarization Lig227 Yes 24.5 ± 1.0 nM
Exp_55 Q61474_RRM1 Fluorescence polarization Lig260 Yes 22.9 ± 1.4 nM
Exp_56 Q61474_RRM1 Fluorescence polarization Lig262 Yes 14.3 ± 1.4 nM
Exp_57 Q61474_RRM1 Fluorescence polarization Lig273 Yes 23.4 ± 1.7 nM
Exp_58 Q61474_RRM1 Fluorescence polarization Lig265 Yes 23.5 ± 1.4 nM
Exp_59 Q61474_RRM1 Fluorescence polarization Lig252 Yes 16 ± 1.3 nM
Exp_60 Q61474_RRM1 Fluorescence polarization Lig292 Yes 14 ± 0.9 nM
Exp_61 Q61474_RRM1 Fluorescence polarization Lig308 Yes 16.3 ± 0.6 nM
Exp_62 Q61474_RRM1 Fluorescence polarization Lig330 Yes 15.8 ± 1.0 nM
Exp_63 Q61474_RRM1 Fluorescence polarization Lig240 Yes 16.4 ± 1.0 nM
Exp_64 Q61474_RRM1 Fluorescence polarization Lig280 Yes 44.8 ± 2.3 nM
Exp_65 Q61474_RRM1 Fluorescence polarization Lig303 Yes 42 ± 1.7 nM
Exp_66 Q61474_RRM1 Fluorescence polarization Lig302 Yes 27.7 ± 2.2 nM
Exp_67 Q61474_RRM1 Fluorescence polarization Lig341 Yes 29.5 ± 1.9 nM
Exp_68 Q61474_RRM1 Fluorescence polarization Lig274 Yes 68 ± 3.0 nM
Exp_69 Q61474_RRM1 Fluorescence polarization Lig332 Yes 128 ± 12.1 nM
Exp_70 Q61474_RRM1 Fluorescence polarization Lig291 Yes 144 ± 11.3 nM
Exp_71 Q61474_RRM1 Fluorescence polarization Lig256 Yes 109.3 ± 6.6 nM
Exp_72 Q61474_RRM1 Fluorescence polarization Lig245 Yes 142.7 ± 7.0 nM
Exp_73 Q61474_RRM1 Fluorescence polarization Lig263 Yes 113.7 ± 6.6 nM
Exp_74 Q61474_RRM1 Fluorescence polarization Lig289 Yes 96.6 ± 6.2 nM
Exp_75 Q61474_RRM1 Fluorescence polarization Lig229 Yes 128.7 ± 18.9 nM
Exp_76 Q61474_RRM1 Fluorescence polarization Lig268 Yes 95.3 ± 4.0 nM
Exp_77 Q61474_RRM1 Fluorescence polarization Lig266 Yes 70.9 ± 2.8 nM
Exp_78 Q61474_RRM1 Fluorescence polarization Lig248 Yes 92.1 ± 11.0 nM
Exp_79 Q61474_RRM1 Fluorescence polarization Lig239 Yes 40.3 ± 1.9 nM
Exp_80 Q61474_RRM1 Fluorescence polarization Lig334 Yes 66.4 ± 2.2 nM
Exp_81 Q61474_RRM1 Fluorescence polarization Lig236 Yes 1953.3 ± 711.6 nM
Exp_82 Q61474_RRM1 Fluorescence polarization Lig271 Yes 1106.7 ± 113.7 nM
Exp_83 Q61474_RRM1 Fluorescence polarization Lig297 Yes 180.3 ± 6.0 nM
Exp_84 Q61474_RRM1 Fluorescence polarization Lig230 Yes 2070 ± 410.7 nM
Exp_85 Q61474_RRM1 Fluorescence polarization Lig277 Yes 1533.3 ± 254.2 nM
Exp_86 Q61474_RRM1 Fluorescence polarization Lig323 Yes 1750 ± 225.2 nM
Exp_87 Q61474_RRM1 Fluorescence polarization Lig264 Yes 2500 ± 348.7 nM
Exp_88 Q61474_RRM1 Fluorescence polarization Lig251 Yes 2460 ± 461.3 nM
Exp_89 Q61474_RRM1 Fluorescence polarization Lig294 Yes 2223.3 ± 142.2 nM
Exp_90 Q61474_RRM1 Fluorescence polarization Lig269 Yes 178.7 ± 10.2 nM
Exp_91 Q61474_RRM1 Fluorescence polarization Lig224 Yes 235.7 ± 10.0 nM
Exp_92 Q61474_RRM1 Fluorescence polarization Lig324 Yes 84 ± 7.4 nM
Exp_93 Q61474_RRM1 Fluorescence polarization Lig283 Yes 149.3 ± 11.0 nM
Exp_94 Q61474_RRM1 Fluorescence polarization Lig327 Yes 133.3 ± 3.0 nM
Exp_95 Q61474_RRM1 Fluorescence polarization Lig313 Yes 110 ± 11.8 nM
Exp_96 Q61474_RRM1 Fluorescence polarization Lig243 Yes 144.3 ± 5.7 nM
Exp_97 Q61474_RRM1 Fluorescence polarization Lig306 Yes 131 ± 9.5 nM
Exp_98 Q61474_RRM1 Fluorescence polarization Lig310 Yes 102.9 ± 2.8 nM
Exp_99 Q61474_RRM1 Fluorescence polarization Lig227 Yes 162 ± 14.0 nM
Exp_100 Q61474_RRM1 Fluorescence polarization Lig260 Yes 137.7 ± 9.1 nM
Exp_101 Q61474_RRM1 Fluorescence polarization Lig262 Yes 91.4 ± 5.6 nM
Exp_102 Q61474_RRM1 Fluorescence polarization Lig273 Yes 144 ± 16.3 nM
Exp_103 Q61474_RRM1 Fluorescence polarization Lig265 Yes 89.6 ± 50.1 nM
Exp_104 Q61474_RRM1 Fluorescence polarization Lig252 Yes 99.7 ± 9.0 nM

Ligands tested for Binding - 46 

Ligand ID Ligand Type Ligand Sequence
Lig166 RNA GUAGU
Lig224 RNA UUUAUAGCUUUU
Lig227 RNA UUUAUAGUUUAU
Lig229 RNA UUAAUAGUUUUU
Lig230 RNA UUUAUCGUUUUU
Lig236 RNA UUUAAAGUUUUU
Lig239 RNA UUUGUAGUUUUU
Lig240 RNA UUUAUUUUUAGUUUUU
Lig243 RNA UUUAUAGUUAUU
Lig245 RNA UAUAUAGUUUUU
Lig248 RNA UUUCUAGUUUUU
Lig251 RNA UUUAUACUUUUU
Lig252 RNA UUUAUAGUUUUG
Lig256 RNA GUUAUAGUUUUU
Lig260 RNA UUUAUAGUUUCU
Lig262 RNA UUUAUAGUUUGU
Lig263 RNA UCUAUAGUUUUU
Lig264 RNA UUUAUAAUUUUU
Lig265 RNA UUUAUAGUUUUC
Lig266 RNA UUGAUAGUUUUU
Lig268 RNA UUCAUAGUUUUU
Lig269 RNA UUUAUAGAUUUU
Lig271 RNA UUUACAGUUUUU
Lig273 RNA UUUAUAGUUUUA
Lig274 RNA UUUAUAGUUUUU
Lig277 RNA UUUAUGGUUUUU
Lig280 RNA UUCAUUAGUUUUU
Lig283 RNA UUUAUAGUAUUU
Lig289 RNA UGUAUAGUUUUU
Lig291 RNA CUUAUAGUUUUU
Lig292 RNA UUUAUUAGUUUUU
Lig294 RNA UUUAUAUUUUUU
Lig297 RNA UUUAGAGUUUUU
Lig302 RNA UUCAUUUUAGUUUUU
Lig303 RNA UUCAUUUAGUUUUU
Lig306 RNA UUUAUAGUUCUU
Lig308 RNA UUUAUUUAGUUUUU
Lig310 RNA UUUAUAGUUGUU
Lig313 RNA UUUAUAGUGUUU
Lig323 RNA UUUAUUGUUUUU
Lig324 RNA UUUAUAGGUUUU
Lig327 RNA UUUAUAGUCUUU
Lig330 RNA UUUAUUUUAGUUUUU
Lig332 RNA AUUAUAGUUUUU
Lig334 RNA UUUUUAGUUUUU
Lig341 RNA UUCAUUUUUAGUUUUU