P09012_RRM1

Protein information

Protein ID: P09012
Protein Name: U1 small nuclear ribonucleoprotein A
Organism: Homo sapiens
Gene Name: SNRPA

Domain information

Pfam ID: PF00076
Pfam Clan Name: RRM
Domain Range: 12 - 83
Domain Length: 72

Domain Sequence

IYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMR

Available Structures for this domain - 150

Experiment ID	RRM Structure	Experiment Type	Ligand ID	Contacts
Exp_1AUD	1AUDA01	NMR	Lig176	Contacts
Exp_1DRZ	1DRZA01	X-ray Diffraction	Lig125	Contacts
Exp_1DZ5	1DZ5B01	NMR	Lig170	Contacts
Exp_1DZ5	1DZ5A01	NMR	Lig170	Contacts
Exp_1FHT	1FHTA01	NMR		No contacts
Exp_1M5K	1M5KF01	X-ray Diffraction	Lig60	Contacts
Exp_1M5K	1M5KC01	X-ray Diffraction	Lig60	Contacts
Exp_1M5O	1M5OF01	X-ray Diffraction	Lig60	Contacts
Exp_1M5O	1M5OC01	X-ray Diffraction	Lig60	Contacts
Exp_1M5P	1M5PF01	X-ray Diffraction	Lig60	Contacts
Exp_1M5P	1M5PC01	X-ray Diffraction	Lig60	Contacts
Exp_1M5V	1M5VF01	X-ray Diffraction	Lig60	Contacts
Exp_1M5V	1M5VC01	X-ray Diffraction	Lig60	Contacts
Exp_1NU4	1NU4B01	X-ray Diffraction		No contacts
Exp_1NU4	1NU4A01	X-ray Diffraction		No contacts
Exp_1OIA	1OIAB01	X-ray Diffraction		No contacts
Exp_1OIA	1OIAA01	X-ray Diffraction		No contacts
Exp_1SJ3	1SJ3P01	X-ray Diffraction	Lig200	Contacts
Exp_1SJ4	1SJ4P01	X-ray Diffraction	Lig200	Contacts
Exp_1SJF	1SJFA01	X-ray Diffraction	Lig200	Contacts
Exp_1U6B	1U6BA01	X-ray Diffraction	Lig186	Contacts
Exp_1URN	1URNC01	X-ray Diffraction	Lig51	Contacts
Exp_1URN	1URNB01	X-ray Diffraction	Lig51	Contacts
Exp_1URN	1URNA01	X-ray Diffraction	Lig51	Contacts
Exp_1VBX	1VBXA01	X-ray Diffraction	Lig200	Contacts
Exp_1VBY	1VBYA01	X-ray Diffraction	Lig200	Contacts
Exp_1VBZ	1VBZA01	X-ray Diffraction	Lig200	Contacts
Exp_1VC0	1VC0A01	X-ray Diffraction	Lig200	Contacts
Exp_1VC5	1VC5A01	X-ray Diffraction	Lig14	Contacts
Exp_1VC6	1VC6A01	X-ray Diffraction	Lig200	Contacts
Exp_1ZZN	1ZZNA01	X-ray Diffraction	Lig186	Contacts
Exp_2A3J	2A3JA01	NMR		No contacts
Exp_2NZ4	2NZ4D01	X-ray Diffraction	Lig88	Contacts
Exp_2NZ4	2NZ4C01	X-ray Diffraction	Lig88	Contacts
Exp_2NZ4	2NZ4B01	X-ray Diffraction	Lig88	Contacts
Exp_2NZ4	2NZ4A01	X-ray Diffraction	Lig88	Contacts
Exp_2OIH	2OIHA01	X-ray Diffraction	Lig47	Contacts
Exp_2OJ3	2OJ3A01	X-ray Diffraction	Lig47	Contacts
Exp_3BO2	3BO2A01	X-ray Diffraction	Lig186	Contacts
Exp_3BO3	3BO3A01	X-ray Diffraction	Lig186	Contacts
Exp_3BO4	3BO4A01	X-ray Diffraction	Lig186	Contacts
Exp_3CUL	3CULB01	X-ray Diffraction	Lig172	Contacts
Exp_3CUL	3CULA01	X-ray Diffraction	Lig172	Contacts
Exp_3CUN	3CUNB01	X-ray Diffraction	Lig172	Contacts
Exp_3CUN	3CUNA01	X-ray Diffraction	Lig172	Contacts
Exp_3EGZ	3EGZA01	X-ray Diffraction	Lig192	Contacts
Exp_3G8S	3G8SD01	X-ray Diffraction	Lig88	Contacts
Exp_3G8S	3G8SC01	X-ray Diffraction	Lig88	Contacts
Exp_3G8S	3G8SB01	X-ray Diffraction	Lig88	Contacts
Exp_3G8S	3G8SA01	X-ray Diffraction	Lig88	Contacts
Exp_3G8T	3G8TD01	X-ray Diffraction	Lig171	Contacts
Exp_3G8T	3G8TC01	X-ray Diffraction	Lig171	Contacts
Exp_3G8T	3G8TB01	X-ray Diffraction	Lig171	Contacts
Exp_3G8T	3G8TA01	X-ray Diffraction	Lig171	Contacts
Exp_3G96	3G96D01	X-ray Diffraction	Lig88	Contacts
Exp_3G96	3G96C01	X-ray Diffraction	Lig88	Contacts
Exp_3G96	3G96B01	X-ray Diffraction	Lig88	Contacts
Exp_3G96	3G96A01	X-ray Diffraction	Lig88	Contacts
Exp_3G9C	3G9CD01	X-ray Diffraction	Lig88	Contacts
Exp_3G9C	3G9CC01	X-ray Diffraction	Lig88	Contacts
Exp_3G9C	3G9CB01	X-ray Diffraction	Lig88	Contacts
Exp_3G9C	3G9CA01	X-ray Diffraction	Lig88	Contacts
Exp_3HHN	3HHND01	X-ray Diffraction	Lig57	Contacts
Exp_3HHN	3HHNB01	X-ray Diffraction	Lig57	Contacts
Exp_3IIN	3IINA01	X-ray Diffraction	Lig186	Contacts
Exp_3IRW	3IRWP01	X-ray Diffraction	Lig74	Contacts
Exp_3IWN	3IWND01	X-ray Diffraction	Lig68	Contacts
Exp_3IWN	3IWNC01	X-ray Diffraction	Lig68	Contacts
Exp_3K0J	3K0JD01	X-ray Diffraction	Lig25	Contacts
Exp_3K0J	3K0JC01	X-ray Diffraction	Lig25	Contacts
Exp_3K0J	3K0JB01	X-ray Diffraction	Lig25	Contacts
Exp_3K0J	3K0JA01	X-ray Diffraction	Lig25	Contacts
Exp_3L3C	3L3CD01	X-ray Diffraction	Lig88	Contacts
Exp_3L3C	3L3CC01	X-ray Diffraction	Lig88	Contacts
Exp_3L3C	3L3CB01	X-ray Diffraction	Lig88	Contacts
Exp_3L3C	3L3CA01	X-ray Diffraction	Lig88	Contacts
Exp_3MUM	3MUMP01	X-ray Diffraction	Lig194	Contacts
Exp_3MUR	3MURP01	X-ray Diffraction	Lig206	Contacts
Exp_3MUT	3MUTP01	X-ray Diffraction	Lig130	Contacts
Exp_3MUV	3MUVP01	X-ray Diffraction	Lig130	Contacts
Exp_3MXH	3MXHP01	X-ray Diffraction	Lig74	Contacts
Exp_3P49	3P49B01	X-ray Diffraction	Lig84	Contacts
Exp_3PGW	3PGWP01	X-ray Diffraction	Lig42	Contacts
Exp_3PGW	3PGWA01	X-ray Diffraction	Lig42	Contacts
Exp_3R1H	3R1HD01	X-ray Diffraction	Lig205	Contacts
Exp_3R1H	3R1HA01	X-ray Diffraction	Lig205	Contacts
Exp_3R1L	3R1LD01	X-ray Diffraction	Lig205	Contacts
Exp_3R1L	3R1LA01	X-ray Diffraction	Lig205	Contacts
Exp_3UCU	3UCUP01	X-ray Diffraction	Lig74	Contacts
Exp_3UCZ	3UCZP01	X-ray Diffraction	Lig74	Contacts
Exp_3UD3	3UD3P01	X-ray Diffraction	Lig206	Contacts
Exp_3UD4	3UD4P01	X-ray Diffraction	Lig206	Contacts
Exp_4C4W	4C4WF01	X-ray Diffraction	Lig66	Contacts
Exp_4C4W	4C4WE01	X-ray Diffraction	Lig66	Contacts
Exp_4C4W	4C4WB01	X-ray Diffraction	Lig66	Contacts
Exp_4C4W	4C4WA01	X-ray Diffraction	Lig66	Contacts
Exp_4PR6	4PR6A01	X-ray Diffraction	Lig10	Contacts
Exp_4PRF	4PRFA01	X-ray Diffraction	Lig200	Contacts
Exp_4W90	4W90B01	X-ray Diffraction	Lig189	Contacts
Exp_4W92	4W92B01	X-ray Diffraction	Lig189	Contacts
Exp_4YB1	4YB1P01	X-ray Diffraction	Lig31	Contacts
Exp_5DDO	5DDOG01	X-ray Diffraction	Lig195	Contacts
Exp_5DDO	5DDOC01	X-ray Diffraction	Lig195	Contacts
Exp_5DDP	5DDPD01	X-ray Diffraction	Lig85	Contacts
Exp_5DDP	5DDPC01	X-ray Diffraction	Lig85	Contacts
Exp_5DDQ	5DDQD01	X-ray Diffraction	Lig85	Contacts
Exp_5DDQ	5DDQC01	X-ray Diffraction	Lig85	Contacts
Exp_5DDR	5DDRD01	X-ray Diffraction	Lig85	Contacts
Exp_5DDR	5DDRC01	X-ray Diffraction	Lig85	Contacts
Exp_5FJ4	5FJ4F01	X-ray Diffraction	Lig215	Contacts
Exp_5FJ4	5FJ4E01	X-ray Diffraction	Lig215	Contacts
Exp_5FJ4	5FJ4B01	X-ray Diffraction	Lig215	Contacts
Exp_5FJ4	5FJ4A01	X-ray Diffraction	Lig215	Contacts
Exp_6LAS	6LASE01	X-ray Diffraction	Lig45	Contacts
Exp_6LAS	6LASD01	X-ray Diffraction	Lig45	Contacts
Exp_6LAS	6LASC01	X-ray Diffraction	Lig45	Contacts
Exp_6LAU	6LAUE01	X-ray Diffraction	Lig45	Contacts
Exp_6LAU	6LAUD01	X-ray Diffraction	Lig45	Contacts
Exp_6LAU	6LAUC01	X-ray Diffraction	Lig45	Contacts
Exp_6LAX	6LAXE01	X-ray Diffraction	Lig8	Contacts
Exp_6LAX	6LAXD01	X-ray Diffraction	Lig8	Contacts
Exp_6LAX	6LAXC01	X-ray Diffraction	Lig8	Contacts
Exp_6LAZ	6LAZE01	X-ray Diffraction	Lig45	Contacts
Exp_6LAZ	6LAZD01	X-ray Diffraction	Lig45	Contacts
Exp_6LAZ	6LAZC01	X-ray Diffraction	Lig45	Contacts
Exp_6QX9	6QX91A01	EM	Lig42	Contacts
Exp_6SQN	6SQNC01	X-ray Diffraction	Lig51	Contacts
Exp_6SQN	6SQNB01	X-ray Diffraction	Lig51	Contacts
Exp_6SQN	6SQNA01	X-ray Diffraction	Lig51	Contacts
Exp_6SQQ	6SQQCCC01	X-ray Diffraction	Lig51	Contacts
Exp_6SQQ	6SQQBBB01	X-ray Diffraction	Lig51	Contacts
Exp_6SQQ	6SQQAAA01	X-ray Diffraction	Lig51	Contacts
Exp_6SQT	6SQTCCC01	X-ray Diffraction		No contacts
Exp_6SQT	6SQTBBB01	X-ray Diffraction		No contacts
Exp_6SQT	6SQTAAA01	X-ray Diffraction		No contacts
Exp_6SQV	6SQVDDD01	X-ray Diffraction		No contacts
Exp_6SQV	6SQVCCC01	X-ray Diffraction		No contacts
Exp_6SQV	6SQVBBB01	X-ray Diffraction		No contacts
Exp_6SQV	6SQVAAA01	X-ray Diffraction		No contacts
Exp_6SR7	6SR7DDD01	X-ray Diffraction		No contacts
Exp_6SR7	6SR7CCC01	X-ray Diffraction		No contacts
Exp_6SR7	6SR7BBB01	X-ray Diffraction		No contacts
Exp_6SR7	6SR7AAA01	X-ray Diffraction		No contacts
Exp_6XH0	6XH0A01	X-ray Diffraction	Lig6	Contacts
Exp_6XH1	6XH1A01	X-ray Diffraction	Lig222	Contacts
Exp_6XH2	6XH2A01	X-ray Diffraction	Lig6	Contacts
Exp_6XH3	6XH3A01	X-ray Diffraction	Lig222	Contacts
Exp_7B0Y	7B0Yc01	EM	Lig42	Contacts
Exp_7D7V	7D7VC01	X-ray Diffraction	Lig219	Contacts
Exp_7LHX	7LHXA01	X-ray Diffraction		No contacts

Ligands tested for Binding - 35

Ligand ID	Ligand Type	Ligand Sequence
Lig10	RNA	GGCCGGCAUGGUCCCAGCCUCCUCGCUGGCGCCGGCUGGGCAACACCAUUGCACUCCGGUGGCGAAUGGGACGGCCGGCAUGGUCCCAGCCUCCUCGCUGGCGCCGGCUGGGCAACACCAUUGCACUCCGGUGGCGAAUGGGAC
Lig125	RNA	GGCCGGCAUGGUCCCAGCCUCCUCGCUGGCGCCGGCUGGGCAACACCAUUGCACUCCGGUGGCGAAUGGGAC
Lig130	RNA	GGUCACGCACAGAGCAAACCAUUCGAAAGAGUGGGACGCAAAGCCUCCGGCCUAAACCAUUGCACUCCGGUAGGUAGCGGGGUUAUCGAUGG
Lig14	RNA	GAUGGCCGGCAUGGUCCCAGCCUCCUCGCUGGCGCCGGCUGGGCAACACCAUUGCACUCCGGUGGCGAAUGGGACU
Lig170	RNA	GAGACAUUGCACCCGGAGUCUC
Lig171	RNA	GGCACCAUUGCACUCCGGUGCCAGUUGACGAGAUGGGGUUUAUCGAGAUUUCGGCGGAUGACUCCCGGUUGUUCAUCACAACCGCAAGCUUUUACUUAAAUCAUUAAGGUGACUUAGUGGACAAAGGUGAAAGUGUGAUGA
Lig172	RNA	GGAUGGCGAAAGCCAUUUCCGCAGGCCCCAUUGCACUCCGGGGUAUUGGCGUUAGGUGGUGGUACGAGGUUCGAAUCCUCGUACCGCAGCCA
Lig176	RNA	GGCAGAGUCCUUCGGGACAUUGCACCUGCC
Lig186	RNA	GGCCGUGUGCCUUGCGCCGGGAAACCACGCAAGGGAUGGUGUCAAAUUCGGCGAAACCUAAGCGCCCGCCCGGGCGUAUGGCAACGCCGAGCCAAGCUUCGCAGCCAUUGCACUCCGGCUGCGAUGAAGGUGUAGAGACUAGACGGCACCCACCUAAGGCAAACGCUAUGGUGAAGGCAUAGUCCAGGGAGUGGCGA
Lig189	RNA	GCGCGCUUAAUCUGAAAUCAGAGCGGGGGACCCAUUGCACUCCGGGUUUUUCCCGUAGGGGUGAAUCCUUUUUAGGUAGGGCGAAAGCCCGAAUCCGUCAGCUAACCUCGUAAGCGCGC
Lig192	RNA	GAGGGAGAGGUGAAGAAUACGACCACCUAGGUACCAUUGCACUCCGGUACCUAAAACAUACCCUC
Lig194	RNA	GGUCACGCACAGAGCAAACCAUUCGAAAGAGUGGGACGCAAAGCCUCCGGCCUAAACCAUUGCACUCCGGUAGGUAGCGGGGUUACCGAUGG
Lig195	RNA	CGUUGGCCCAGGAAACUGGGUGGAAGUAAGGUCCAUUGCACUCCGGGCCUGAAGCAACGCU
Lig200	RNA	GAUGGCCGGCAUGGUCCCAGCCUCCUCGCUGGCGCCGGCUGGGCAACACCAUUGCACUCCGGUGGUGAAUGGGACU
Lig205	RNA	GGAACACUAUACUACUGGAUAAUCAAAGACAAAUCUGCCCGAAGGGUUUGAGAACAUACCCAUUGCACUCCGGGUAUGCAGAGGUGGCAGCCUCCGGUGGGUUAAAACCCAACGUUCUCAACAAUAGUGA
Lig206	RNA	GGUCACGCACAGGGCAAACCAUUCGAAAGAGUGGGACGCAAAGCCUCCGGCCUAAACCAUUGCACUCCGGUAGGUAGCGGGGUUAUCGAUGG
Lig215	RNA	GAGGGAGCGCCAUUGCACUCCGGUGCGAAGAACUC
Lig219	RNA	GCGCAACAUCCCCGCCGGUUGGGCGCAUUGCACUCCGCGCAGUGAACCGGCUGCGCC
Lig222	RNA	GGAGAUCUGAGCCUGGGAGCUCUCUCC
Lig25	RNA	GCGACUCGGGGUGCCCUCCAUUGCACUCCGGAGGCUGAGAAAUACCCGUAUCACCUGAUCUGGAUAAUGCCAGCGUAGGGAAGUCGC
Lig31	RNA	GGGCACGCACAGAGCAAACCAUUCGAAAGAGUGGGACGCAAAGCCUCCGGCCUAAACCAUUGCACCUCGGUAGGUAGCGGGGUUACCGAUG
Lig42	RNA	AUACUUACCUGGCAGGGGAGAUACCAUGAUCACGAAGGUGGUUUUCCCAGGGCGAGGCUUAUCCAUUGCACUCCGGAUGUGCUGACCCCUGCGAUUUCCCCAAAUGUGGGAAACUCGACUGCAUAAUUUGUGGUAGUGGGGGACUGCGUUCGCGCUUUCCCCUG
Lig45	RNA	GGCAUUGUGCCUCGCAUUGCACUCCGCGGGGCGAUAAGUCCUGAAAAGGGAUGUC
Lig47	RNA	GAUGGCCGGCAUGGUCCCAGCCUCCUCGCUGGCGCCGGCUGGGCAACACCAUUGCACUCCGGUGGUGAAUGGGAC
Lig51	RNA	AAUCCAUUGCACUCCGGAUUU
Lig57	RNA	UCCAGUAGGAACACUAUACUACUGGAUAAUCAAAGACAAAUCUGCCCGAAGGGCUUGAGAACAUACCCAUUGCACUCCGGGUAUGCAGAGGUGGCAGCCUCCGGUGGGUUAAAACCCAACGUUCUCAACAAUAGUGA
Lig6	RNA	GCAGAUCUGAGCCUGGGAGCUCUCUGC
Lig60	RNA	GGAGAGAGAAGUCAACCAGAGAAACACACCAACCCAUUGCACUCCGGGUUGGUGGUAUAUUACCUGGUACGGGGGAAACUUCGUGGUGGCCG
Lig66	RNA	GAGCAAGAGCCAUUGCACUCCGGUUUGAUGACCUC
Lig68	RNA	CACGCACAGGGCAAACCAUUCGAAAGAGUGGGACGCAAAGCCUCCGGCCUAAACGGCAUUGCACUCCGCCGUAGGUAGCGGGGUUACCGAUGG
Lig74	RNA	GGUCACGCACAGGGCAAACCAUUCGAAAGAGUGGGACGCAAAGCCUCCGGCCUAAACCAUUGCACUCCGGUAGGUAGCGGGGUUACCGAUGG
Lig8	RNA	GGCAUCGUGCCUCGCAUUGCACUCCGCGGGGCGAUAAGUCCUGAAAAGGGAUGUC
Lig84	RNA	GGAUAUGAGGAGAGAUUUCAUCCAUUGCACUCCGGAUGAAACACCGAAGAAGUAAAUCUUUCAGGUAAAAAGGACUCAUAUUGGACGAACCUCUGGAGAGCUUAUCUAAGAGAUAACACCGAAGGAGCAAAGCUAAUUUUAGCCUAAACUCUCAGGUAAAAGGACGGAG
Lig85	RNA	CGUUGACCCAGGAAACUGGGCGGAAGUAAGGUCCAUUGCACUCCGGGCCUGAAGCAACGCG
Lig88	RNA	GGCACCAUUGCACUCCGGUGCCAGUUGACGAGGUGGGGUUUAUCGAGAUUUCGGCGGAUGACUCCCGGUUGUUCAUCACAACCGCAAGCUUUUACUUAAAUCAUUAAGGUGACUUAGUGGACAAAGGUGAAAGUGUGAUGA