Protein Name : Peptidyl-prolyl cis-trans isomerase E
Gene : PPIE
Organism : Homo sapiens
Status : reviewed
Function : Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638 PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:8977107 PubMed:18258190 PubMed:20677832 PubMed:20460131). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:8977107 PubMed:18258190 PubMed:20460131). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:8977107 PubMed:18258190 PubMed:20677832 PubMed:20541251). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20677832 PubMed:20541251 PubMed:20460131).