Peptidyl-prolyl cis-trans isomerase E

Protein information

  • Protein ID: Q9UNP9
  • Protein Name : Peptidyl-prolyl cis-trans isomerase E
  • Gene : PPIE
  • Organism : Homo sapiens
  • Status : reviewed
  • Function : Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638 PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:8977107 PubMed:18258190 PubMed:20677832 PubMed:20460131). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:8977107 PubMed:18258190 PubMed:20460131). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:8977107 PubMed:18258190 PubMed:20677832 PubMed:20541251). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20677832 PubMed:20541251 PubMed:20460131).

Protein Sequence

  • MATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETEKHRGFAFVEFELAEDAAAAIDNMNESELFGRTIRVNLAKPMRIKEGSSRPVWSDDDWLKKFSGKTLEENKEEEGSEPPKAETQEGEPIAKKARSNPQVYMDIKIGNKPAGRIQMLLRSDVVPMTAENFRCLCTHEKGFGFKGSSFHRIIPQFMCQGGDFTNHNGTGGKSIYGKKFDDENFILKHTGPGLLSMANSGPNTNGSQFFLTCDKTDWLDGKHVVFGEVTEGLDVLRQIEAQGSKDGKPKQKVIIADCGEYV

RRM domains in this Protein - 1 

RRM Entryname RRM Sequence range Pfam ID
Q9UNP9_RRM1 8 - 78 PF00076

Experiments retrieved for this Protein - 15 

Experiment ID Experiment Type PubMed ID
Exp_2CQB NMR
Exp_2KU7 NMR 20541251
Exp_2KYX NMR 20677832
Exp_3LPY X-ray Diffraction 20541251
Exp_3MDF X-ray Diffraction 20460131
Exp_5MQF EM 28076346
Exp_5YZG EM 29301961
Exp_5Z56 EM 29360106
Exp_5Z57 EM 29360106
Exp_6FF7 EM 29361316
Exp_6ICZ EM 30728453
Exp_6ID0 EM 30728453
Exp_6ID1 EM 30728453
Exp_7A5P EM 33007253
Exp_7ABI EM 33243851

Ligands tested for Binding - 3 

Ligand ID Ligand Type Ligand Sequence
Lig109 RNA GAAUACACGGAAUUCGAGCUCGCCCACUCUUGGAUCGGAAACCCGUCGGCCUCCGAACGGUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCGUACACCAUCAGGGUACGUACUAGUACGUACACCAUCAGGGUACGGCUGCACGUCUAGGGCGCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACAGCUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCC
Lig48 RNA GGGAGACGGAAUUCGAGCUCGCCCACUCUUGGAUCGGAAACCCGUCGGCCUCCGAACGGUAAGAGCCUAGCAUGUAGAACUGGUUACCUGCAGCCCAAGCUUGCUGCACGUCUAGGGCGCAGUAGUCCAGGGUUUCCUUGAUGAUGUCAUACUUAUCCUGUCCCUUUUUUUUCCACAGCUCGCGGUUGAGGACAAACUCUUCGCGGUCUUUCCAGUGGGGAUCCGAUAUCCGUACACCAUCAGGGUACGAGCUAGCCCAUGGCGUACACCAUCAGGGUACGACUAGUAGAUCUCGUACACCAUCAGGGUACGGAAUUCUCUAGA
Lig80 RNA AUCGCUUCUCGGCCUUUUGGCUAAGAUCAAGUGUAGUAUCUGUUCUUAUCAGUUUAAUAUCUGAUACGUCCUCUAUCCGAGGACAAUAUAUUAAAUGGAUUUUUGGAGCAGGGAGAUGGAAUAGGAGCUUGCUCCGUCCACUCCACGCAUCGACCUGGUAUUGCAGUACCUCCAGGAACGGUGCACCC